醫學院 - 全職教學人員

朱文德(John)

助理教授(神經科學)

所在部門：醫學院(FMD)

辦公室：擎天匯校區 PP-R206B

電子信箱： mtchu@must.edu.mo

Dr. Chu is an Assistant Professor in the Faculty of Medicine at Macau University of Science and Technology (MUST). He obtained his undergraduate and PhD from Hong Kong Baptist University. Before joining MUST, he has completed his postdoctoral training from University of Hong Kong, where he developed a strong foundation in biomedical research. His research focuses on the pathogenesis of neurocognitive disorders, with a particular emphasis on the interplay between systemic immune responses and neuroinflammation. Dr. Chu’s work explores how systemic inflammation, induced by conditions such as surgical interventions or metabolic disorders, contributes to neuroinflammatory processes and subsequent cognitive impairment. By integrating cutting-edge methodologies, Dr. Chu research goal is to advance the understanding of the molecular and cellular mechanisms underlying neurocognitive dysfunction and pioneer novel therapeutic strategies to mitigate its impact.

學歷

PhD in Biology, Hong Kong Baptist University

BSc in Applied Biology, Hong Kong Baptist University

教學領域

Neuroscience, Neurodegeneration, Neuropharmacology

研究領域

Neurodegeneration,

Neuroimmune Response,

Immunometabolism in Neurocognitive Disorders,

Neuroprotective Strategies

工作經歷

Assistant Professor, Macau University of Science and Technology (Jul 2025 – present)

Research Officer, The University of Hong Kong (Oct 2021 – Jun 2025)

Assistant Research Officer, The University of Hong Kong (Sep 2018 – Sep 2021)

Postdoctoral Fellow, The University of Hong Kong (Jul 2014 – Aug 2018)

Postdoctoral Fellow, Hong Kong Baptist University (Sep 2011 – Jun 2014)

學術出版物（精選）

1. Y. Chen, John M.T. Chu, J. Liu, Y. Duan, Z Liang, X. Zou, M. Wei, W. Xin, T. Xu, Gordon T.C. Wong and X. Feng (2025) Double negative T cells promote surgery-induced neuroinflammation, microglial engulfment and cognitive dysfunction via the IL-17/CEBPβ/C3 pathway in adult mice. Brain, Behavior and Immunity. 123: 965-81.https://doi.org/10.1016/j.bbi.2024.10.029

2. Michael S.L. Lai, M.H. Sørensen, K. Lee, John M.T. Chu and Raymond C.C. Chang (2024) 3D Mapping of Direct VTA-CA2 Circuit with Potential Involvement in Parkinson's Disease Degeneration. Neurobiology of Disease. https://doi.org/10.1016/j.nbd.2024.106723

3. John M.T. Chu, Suki P.W. Chiu, J. Wang, Raymond C.C. Chang and Gordon T.C. Wong (2024) Adiponectin deficiency is a critical factor contributing to cognitive dysfunction in obese mice after sevoflurane exposure. Molecular Medicine. 30:177. https://doi.org/10.1186/s10020-024-00954-0

4. Y. Chen, John M.T. Chu, Raymond C.C. Chang and Gordon T.C. Wong (2024). Complement C3 From Astrocytes Plays Significant Roles in Sustained Activation of Microglia and Cognitive Dysfunctions Triggered by Systemic Inflammation After Laparotomy in Adult Male Mice. Journal of Neuroimmune Pharmacology. 19, 8. https://doi.org/10.1007/s11481-024-10107-z

5. J. Wang, Raymond C.C. Chang, John M.T. Chu * and Gordon T.C. Wong * (2024). Is adiponectin deficiency a critical factor for sevoflurane induced neurocognitive dysfunction? Medical Hypotheses. https://doi.org/10.1016/j.mehy.2023.111241. (* Co-corresponding author)

6. Y. Chen, J Joo, John M.T. Chu, Raymond C.C. Chang and Gordon T.C. Wong (2023). Downregulation of the glucose transporter GLUT 1 in the cerebral microvasculature contributes to postoperative neurocognitive disorders in aged mice. Journal of Neuroinflammation. 20:237. https://doi.org/10.1186/s12974-023-02905-8

7. Y. Liu, John M.T. Chu, R. You, Y. Zhang, Raymond C.C. Chang and Gordon T.C. Wong (2022). Prehabilitative resistance exercise reduces neuroinflammation and improves mitochondrial health in aged mice with perioperative neurocognitive disorders. Journal of Neuroinflammation. 19:150. https://doi.org/10.1186/s12974-022-02483-1

8. C. Huang *, John M.T. Chu *, Y. Liu, Vivian S.W. Kwong, Raymond C.C. Chang and Gordon T.C. Wong (2022) Sevoflurane induces neurotoxicity in the animal model with Alzheimer's disease neuropathology via modulating glutamate transporter and neuronal apoptosis. International Journal of Molecular Sciences. 23, 6250. https://doi.org/10.3390/ ijms23116250 (*Authors share equal contributions)

9. Y. Zhang, John M.T. Chu and Gordon T.C. Wong (2022) Cerebral glutamate regulation and receptor changes in perioperative neuroinflammation and cognitive dysfunction. Biomolecules. 12, 597. https://doi.org/10.3390/biom12040597

10. John M.T. Chu, A. Abulimiti, Brian S.H. Wong, G. Zhao, S. Xiong, M. Zhao, Y. Wang, Y. Chen, Adora J. Wang, Y. Zhang, Raymond C.C. Chang, H. Yu and Gordon T.C. Wong (2022) Sigesbeckia orientalis L. derived active fraction ameliorated perioperative neurocognitive disorder through alleviating hippocampal neuroinflammation. Frontiers in Pharmacology. doi: 10.3389/fphar.2022.846631

11. Y. Chen, John M.T. Chu, Raymond C.C. Chang and Gordon T.C. Wong (2022) The complement system in the central nervous system: from neurodevelopment to neurodegeneration. Biomolecules. 12, 337. doi: https://10.3390/biom12020337

12. Y. Liu, John M.T. Chu, Y. Tim, Y. Zhang, Y. Chen, Raymond, C.C. Chang and Gordon T.C. Wong (2020) Short-term resistance exercise inhibits neuroinflammation and attenuates neuropathological changes in 3xTg Alzheimer’s disease mice. Journal of Neuroinflammation. 17, 4

13. C. Huang, Olivia T.W. Ng, John M.T. Chu, Michael G. Irwin, X. Hu, S. Zhu, Raymond C.C. Chang and Gordon T.C. Wong (2019) Differential effects of propofol and dexmedetomidine on neuroinflammation induced by systemic endotoxin lipopolysaccharides in adult Mice. Neuroscience Letters. 707, 134309

14. Y. Liu, Y. Tim, John M.T. Chu, Y. Chen, S. Dunnett, Y.S. Ho, Gordon T.C. Wong and Raymond C.C. Chang (2019) The beneficial effects of physical exercise in the brain and related pathophysiological mechanisms in neurodegenerative diseases. Laboratory Investigation. 99, 943-957

15. John M.T. Chu, W. Xiong, K.G. Linghu, Y. Liu, Y. Zhang, G.D. Zhao, M.G. Irwin, Gordon T.C. Wong and H. Yu (2018) Siegesbeckia Orientalis L. extract attenuates postoperative cognitive dysfunction, systemic inflammation, and neuroinflammation. Experimental Neurobiology. 27(6):564-573

16. W. Xiong, G.D. Zhao, X. Yin, K.G. Linghu, John M.T. Chu, Gordon T.C. Wong, H. Li, H. Yu and Y.T. Wang (2018) Brij-grafted-chitosan copolymers with function of P-glycoprotein modulation: Synthesis, characterization and in vitro investigations. Carbohydrate Polymers. 204: 89-96

17. C. Huang, John M.T. Chu, Y. Liu, Raymond C.C. Chang and Gordon T.C. Wong (2018) Varenicline reduces DNA damage, tau mislocalization and post surgical cognitive impairment in aged mice. Neuropharmacology. 143: 217-227

18. John M.T. Chu, K.M. Lee, Daniella P.K. Wong, Gordon T.C. Wong and Kevin K.M. Yue (2016) Methylglyoxal-induced neuroinflammatory response in in vitro astrocytic cultures and hippocampus of experimental animals. Metabolic Brain Disease. 31(5): 1055-1064.

19. John M.T. Chu, K.M. Lee, Daniella P.K. Wong, Ricky N.S. Wong, Ken K.L. Yung, Christopher H.K. Cheng and Kevin K.M. Yue (2014) Ginsenosides attenuate methylglyoxal-induced impairment of insulin signaling and subsequent apoptosis in primary astrocytes. Neuropharmacology. 85: 215-223

20. Daniella P.K. Wong *, John M.T. Chu *, Victor K.L. Hung, Dicky K.M. Lee, Christopher H.K. Cheng, Ken K.L. Yung and Kevin K.M. Yue (2013) Modulation of endoplasmic reticulum chaperone GRP78 by high glucose in hippocampus of streptozotocin-induced diabetic mice and C6 astrocytic cells. Neurochemistry International. 63: 551-560 (*Authors share equal contributions)

21. John M.T. Chu, Y.S. Chan, L.W. Chen and Ken K.L. Yung (2012) Neurokinin receptor 3 peptide exacerbated 6-OHDA induced dopaminergic degeneration in rats through JNK pathway. Journal of Neurochemistry. 123: 417-427

22. John M.T. Chu, L.W. Chen, Y.S. Chan and Ken K.L. Yung (2011) Neuroprotective effects of neurokinin receptor one in dopaminergic neurons are mediated through Akt/PKB cell signaling pathway. Neuropharmacology. 61(8): 1389-1398

書籍

專利

專業認證和獎項

2018-2022 Investigating the use of a naturally occurring anti-inflammatory herbal, Siegesbeckia Herba in minimising postoperative cognitive dysfunction

Funding Source: Health and Medical Research Fund, HKSAR government (HKD 1,179,656; Role: Co-Investigator)

2015-2017 Advancement for developing drug against Lewy Body Dementia by establishing a pre-clinical experimental model

Funding Source: HKU Seed Funding for Applied Research, HKU (HKD 100,000; Role: Co-Investigator)

專業協會會員資格

Member, Japanese Neuroscience Society (2008-2011)