2011-2016 Ph.D. in Biochemistry; King Abdulaziz University, Jeddah,  Saudi Arabia

2006-2010 BS (Hons) Biotechnology University of Malakand, KP, Pakista

Microbiology, Biotechnology, Immunology, Molecular Biology, Molecular Diagnostics

Host-Microbe interaction, Microbiome, Human Diseases, Herbal products, Chinese Medicine

Assistant Professor, Faculty of Medicine, Macau University of Science and Technology, Macau SAR (Jul 2025-Continue)

 Assistant Professor, Department of Biotechnology; Abdul Wali Khan University Mardan, Pakistan (Aug 2022-Jun 2025)

QEC coordinator/MIS Focal Person, Department of Biotechnology; Abdul Wali Khan University Mardan, Pakistan  (13 July, 2024 – Jun 2025).

Senior Lecturer; Biotechnology Research Institute, University of Malaysia Sabah, Malaysia (Mar-Aug 2022)

Global Talent Fellow; Macau University of Science and Technology, Macau (Sept 2019 to Aug 2021).

Postdoc Fellow at Hsioa Lab, Macau University of Science and Technology, Macau (July 2016 to Aug 2019).

Research Associate; National Institute for Biotechnology and Genetic Engineering, Pakistan (Mar-Nov 2011)

1.     Li X., Gouxin H., Khan I., Ding Z.  Hsiao WLW., Liu Z. (2025). The Prebiotic Effect of Kaempferol in Regulating Bile Acid Metabolism. Food Science and Nutrition. Volume 13:e70023. DOI: https://doi.org/10.1002/fsn3.70023. Impact Factor 3.55 (2025). Q1.

2.     Khan I*,#., Gouxin H., Khan S., Ali A. Editorial: The roles of pathogens in gut-related diseases and the strategies for inhibiting their growth. (Published: 04.12.2024). Frontiers in Pharmacology. Volume 14. DOI: 10.3389/fphar.2024.1513694. Impact Factor 4.4 (2023). Q1

3.     Li X*., Khan I*, Han R., Huang G., Xia W., Lin Y., Leong WK., Su L., Betty YKL., Vincent KWW., Wu Q., Guo X., Hsiao WLW.Gynostemma Pentaphyllum Saponins Shield Mice from Peanut Allergy by Modulation of Gut Microbiota: A Novel Approach for Peanut Allergy Management. (Published: December 2024). Phytomedicine. Impact Factor 6.7 (2022). Q1

4.     Huang G., Wang J., Yin L., Khan I., Betty YKL., Zheng Y., Xu M., Vincent KWW., Hsiao WLW. Published: 18.09.2024)The impact of test anxiety on oral microbiota among medical students-A pilot study. Stress and Health. DOI: 10.1002/smi.3479. Q1

5.     Huang G, Khan R, Yilin Zheng, Ping Chin Lee, Qingnan Li and Khan I*. Exploring the role of gut microbiota in advancing personalized medicine”. (published: 2023/11/30). Frontiers in Microbiology.volume 14. DOI: 10.3389/fmicb.2023.1274925.  Impact Factor 5.2 (2022). Q1

6.     Khan I*. Editorial: Drugs and gut microbiome interactions—an emerging field of tailored medicine. (Published: 30.08.2023). BMC Pharmacology and Toxicology. 24(1).43. DOI: https://doi.org/10.1186/s40360-023-00684-9. Impact Factor 2.9 (2022). Q1

7.     Khan I*. Editorial: Nutrition to support gut health and the microbiome in athletes. Frontiers in Nutrition. Volume 10 – 2023. DOI: 10.3389/fnut.2023.1207543. Impact Factor 6.6 (2022). Q1

8.     R Khan, MD Shah, L Shah, LP Chin, I Khan*. Bacterial polysaccharides–a big source for prebiotics and therapeutics. Frontiers in Nutrition. (published: 2022/11/3). Frontiers in Nutrition. 1-20. DOI:10.3389/fnut.2022.1031935. Impact Factor 6.8 (2022).

9.     Wang, Jian; Feng, Zhe-Xiang; Ren, Tao; Meng, Wei-Yu; Khan I; Fan, Xing-Xing; Pan, Hu-Dan; Liu, Liang; Tang, Yi-Jun; Yao, Xiao-Jun; Li, Run-Ze, Wang, Mei-Fang; Leung, Elaine Lai-Han. Novel clinical biomarkers in blood and pleural effusion for diagnosing patients with tuberculosis distinguishing from malignant tumor. (Published 14 Oct 2022). Journal of Medicine. DOI:10.1097/MD.0000000000031027. Impact Factor 1.55 (2022)

10.   L Yin, G Huang, Khan I, L Su, W Xia, BYK Law, VKW Wong, Q Wu, J Wang, Wai Kit Leong, WL Hsiao. Poria cocos polysaccharides exert prebiotic function to attenuate the adverse effects and improve the therapeutic outcome of 5-FU in ApcMin/+ mice. (published: 2022/10/3). Journal of Chinese Medicine. 17 (1). 1-14. DOI: 10.1186/s13020-022-00667-8. Impact Factor 4.55 (2022)

11.   Li X#, Khan I#, Huang G, Lu Y, Wang L, Liu Y, Lu L, Hsiao WLW, Liu Z. Kaempferol acts on bile acid signaling and gut microbiota to attenuate the tumor burden in ApcMin/+ mice. (Published: 05 Mar 2022). European Journal of Pharmacology.918:174773. DOI: 10.1016/j.ejphar.2022.174773. Impact Factor 4.4 (2021).

12.   Waikit L, Guoxin H., Weilin L., Wenrui X., Xiaoang L., Ziren S., Liang L., Qiang W., Vincent K.W.W., Betty Y.K.L., Chenglai X., Xiaoling G., Khan I*.  and W.L. Wendy*. Traditional Patchouli Essential Oil modulates the host’s immune responses and gut microbiota and exhibits potent anti-cancer effects in ApcMin/+ mice. (Published: 2022 Jan 12). Pharmacological Research.106082. DOI: 10.1016/j.phrs.2022.106082. Impact Factor 7.66 (2020).

13.   Gouxin H, M Yasir, Y Zheng, Khan I#. Prebiotic properties of jiaogulan in the context of gut microbiome. (Published: 22 Jan 2022). Food Science and Nutrition. DOI: 10.1002/fsn3.2701. Impact Factor 3.55 (2020).

14.   Kural A., Khan I*, Seyit H, Caglar TR, Toklu P, Vural M. Changes in the gut microbiota of morbidly obese patients after laparoscopic sleeve gastrectomy. (Published: 2021 Dec. 08). 17:5-15. DOI: 10.2217/fmb-2021-0043. Future Microbiology. Impact Factor 3.17 (2020).

15.   Ali F., Khan I, Chen J, Akhtar K, Bakhsh EM, Khan SB. Emerging Fabrication Strategies of Hydrogels and Its Applications. (Published 24 Mar 2022). Gels, 8(4), 205. DOI: 10.3390/gels8040205. Impact Factor 4.7 (2022).

16.   Yasir M., Khan R., Ullah R., Bibi F., Khan I., Mustafa A., Ghamdi A., Azhar EI. Bacterial diversity and the antimicrobial resistome in the southwestern highlands of Saudi Arabia. (2021). Saudi Journal of Biological Sciences. 29(4):2138-2147. DOI: 10.1016/j.sjbs.2021.11.047. (Published: 24 November 2021). Impact Factor 4.129 (2020).

17.   Wang J., Feng ZX, Ren T., Khan I., Fan X, Pan HD, Liu L., Tang YJ., Li RZ., Wang MF, Leung ELH. Novel clinical biomarkers in blood and pleural effusion for diagnosing patients with tuberculosis distinguishing from malignant tumour. (Published: November 2021). Research Square. 58:102924. DOI: 10.21203/rs.3.rs-1049353/v1.

18.   Chen J., Ali F., Khan I*, Zhua YZ*. (2021). Recent progress in the development of potential drugs against SARS-CoV-2. Current Research in Pharmacology and Drug Discovery. Volume 2, 2021, 100057. (Published: 2021 Sep 14). doi.org/10.1016/j.crphar.2021.100057.

19.   Wu Zeng, An Guo Wu, Khan I, Rui Long Zhang, Hang Hong Lo, Li Qun Qu, Lin Lin Song, Yuan Xiao Yun, Chen Juen, Jerome P. L. Ng, Si Yu Yuan, Yu Lu, Yong Tang, Vincent Kam-Wai Wong, Sookja Chung, Da Lian Qin, Simon Wing Fai Mok, Hualin Sun, Wen Luan Wendy Hsiao and Betty Yuen-Kwan Law. Saponins isolated from Radix polygalae extent lifespan by modulating complement C3 and gut microbiota. (Published: 2021 May 25). DOI: 10.1016/j.phrs.2021.105697. Pharmacological Research. Impact Factor 7.66 (2020).

20.   Huang J, Liu D, Wang Y, Liu L, Li J, Yuan J, Jiang Z, Jiang Z, Hsiao WW, Liu H, Khan I, Xie Y, Wu J, Xie Y, Zhang Y, Fu Y, Liao J, Wang W, Lai H, Shi A, Cai J, Luo L, Li R, Yao X, Fan X, Wu Q, Liu Z, Yan P, Lu J, Yang M, Wang L, Cao Y, Wei H, Leung EL. Ginseng polysaccharides alter the gut microbiota and kynurenine/tryptophan ratio, potentiating the anti-tumor effect of anti-programmed cell death 1 /programmed cell death ligand 1 (anti-PD-1/PD-L1) immunotherapy. (Published: 2021 May 18). Gut. 71(4):734-745. DOI: 10.1136/gutjnl-2020-321031. Impact Factor 23.059 (2020).

21.   Xiaoang Li#, Khan I#, Xia W, Huang G, Liu L, Kwan Law BY, Lin Yin, Liao W, Leong W, Han R, Wai Wong VK, Xia C, Guo X, W.L. Wendy Hsiao. Icariin enhances youth-like features by attenuating the declined gut microbiota in the aged mice. (Published: 2021 Mar 30). DOI: 10.1016/j.phrs.2021.105587. Pharmacological Research. Impact Factor 7.66 (2020).

22.   Rehman F, Cheema T, Azeem T, Naseem A, Khan I, Iqbal N, Shaheen A, Rehman F, Rehman Q. (Published: 22 November 2020). Groundwater quality and potential health risks caused by arsenic (As) in Bhakkar, Pakistan. Environmental Earth Sciences. 79:529. DOI: 10.1007/s12665-020-09270-2. Impact Factor 2.78 (2020).

23.   Huan-Ling Lai, Pei-Pei Chen, Dan Li, Khan I, Hsiao Wen Luan, Wendy, Fan Xing Xing,Yao Xiao Jun, Wu Qi Biao, Mei-Fang Wang, Leung Lai Han. Clinical significance of LSECtin and its association with PVR in non-small-cell lung cancer patients. (Published: November 2020). Annals of Translational Medicine. 8(21):1393. DOI: 10.21037/atm-20-3665. Impact Factor 3.93 (2020).

24.   Weilin Liao#, Khan I#, Huang G, Shengshuang Chen, Liu L, Wai Kit Leong, Xiao ang Li, Jianlin Wu & W.L.W Hsiao. Bifidobacterium animalis - the missing link for the cancer-preventive effect of Gynostemma pentaphyllum. (Published: 24 November 2020). Gut Microbes. 13(1):1847629. DOI: 10.1080/19490976.2020.1847629. Pages 1-14. Impact Factor 10.245 (2020).

25.   Wenrui Xia, Lu Su, Khan I, Xiaoang Li, Wai Kit Leong, Lin Yin, Xiqing Bian, Jiyan Su, Guoxin Huang & W.L. Wendy Hsiao. Lycium berry polysaccharides strengthen gut microenvironment and modulated gut microbiota of the mice. (Published: 5 October 2020). Evidence-Based Complementary and Alternative Medicine. Vol 2020. Pages 10. DOI: 10.1155/2020/8097021. Impact Factor 2.629 (2020).

26.   You H, Zhang YZ, Lai HL, Li D, Liu YQ, Li RZ, Khan I, Hsiao WW, Duan FG, Fan XX, Yao XJ, Cao YB, Wu QB, Leung EL, Wang MF. Prognostic significance of tumor poliovirus receptor and CTLA4 expression in patients with surgically resected non-small-cell lung cancer. (Published: 4 April 2020). Journal of Cancer Research and Clinical Oncology. 146(6):1441-1450. DOI: 10.1007/s00432-020-03189-8. Impact Factor 4.55 (2020).

27.   Xia W#, Khan I#, Li X, Wai Leong K, Yu Z, Huang G, Han R, Tsun Ho T, Hsiao W.L.W. Adaptogenic flower buds exert cancer-preventive effects by enhancing the SCFA-producers, strengthening the epithelial tight junction complex and immune responses. (Published: 3 June 2020). Pharmacological Research. 159:104809.  DOI: 10.1016/j.phrs.2020.104809. Impact Factor 7.66 (2020).

28.   Khan I, Li X, Law B, U KI, Pan BQ, Lei C, W.L.W. Hsiao. Correlation of gut microbial compositions to the development of Kawasaki disease vasculitis in children. (Published: 15 April 2020). Future Microbiology. 15:591-600. DOI: 10.2217/fmb-2019-0301. Impact Factor 3.19 (2020).

29.   Chia L#, Khan I#, Lina Z, Zhang J, M.Y. Simon Lee, Leong W, Hsiao WL, Zheng Y. Fructo-oligosaccharides from Morinda officinalis remodeled gut microbiota and alleviated depression features in a stress rat model. (Published: Feb 2020). Phytomedicine. 67:153157. DOI: 10.1016/j.phymed.2019.153157. Impact Factor 5.34 (2020).

30.   Khan I, Sabrina Pathan, Xiao Ang Li, Wai Kit Leong, Wei Lin Liao, Vincent Wong, W.L. Wendy Hsiao. Far infrared radiation induces changes in gut microbiota and activates host’s GPCRs in mice. (Published: March 2020). Journal of Advanced Research. 22:145-152. DOI: 10.1016/j.jare.2019.12.003. Impact Factor 10.479 (year 2020).

31.   Fu-Gang Duan, Mei-Fang Wang, Ya-Bing Cao, Dan Li, Run-Ze Li, Xing-Xing Fan, Khan I, Huan-Ling Lai, Yi-Zhong Zhang, Wendy Wen-Luan Hsiao, Xiao-Jun Yao, Qi-Biao Wu, Liang Liu, Yi-Jun Tang & Elaine Lai-Han Leung. (2019). MicroRNA-421 confers paclitaxel resistance by binding to the KEAP1 3′UTR and predicts poor survival in non-small cell lung cancer. Cell Death & Disease. 10(11):821. DOI: 10.1038/s41419-019-2031-1. Impact Factor 5.959 (2018).

32.   Leong W, Huang G, Khan I, Xia W, Li Y, Liu Y, Li X, Han R, Su Z, WL Wendy. Patchouli essential oil and its derived compounds revealed prebiotic-like effects in C57BL/6J mice. (published: 17 Oct 2019). 10:1229. DOI: 10.3389/fphar.2019.01229. Frontiers in Pharmacology. Impact Factor 4.2 (2019).

33.   Khan I#, Huang G#, Li X, Liao W, Leong W, Xia W, Bian X, Wu J, Hsiao WLW. Mushroom polysaccharides and jiaogulan saponins exert cancer preventive effects by shaping the gut microbiota and microenvironment in ApcMin/+ mice. (Published: October 2019). Pharmacological Research. DOI: 10.1016/j.phrs.2019.104448. Impact Factor 5.89 (2019).

34.   Khan I, Muhammad Yasir, Muhammad Farman, Taha Kumosani, Samera F. AlBasri, Osama S. Bajouh, Wendy Hsiao, Esam I. Azhar. Evaluation of gut bacterial community composition and antimicrobial resistome in Saudi population. (21 June, 2019). Infection and Drug Resistance. 2019(12): 1749—1761. DOI: https://doi.org/10.2147/IDR.S200213. Impact Factor 3.4 (2018).

35.   Khan I#, Huang G#, Xiaoang Li, Waikit Leong, Wenrui Xia, W.L. Wendy Hsiao. Mushroom polysaccharides from Ganoderma lucidum and Poria cocos reveal prebiotic functions. (2018). Journal of Functional Foods. 41: 191–201. DOI: 10.1016/j.jff.2017.12.046. Impact Factor 4.1 (2017).

36.   Qureshi, Q.A, Yasir M, Khan I, Fehmida Bibi,1 Esam I Azhar. Culturomics-based taxonomic diversity of bacterial communities in the hot spring of Saudi Arabia. (2018). OMICS: A Journal of Integrative Biology. 23(1):17-27. DOI: 10.1089/omi.2018.0176. Impact Factor 2.61 (2017).

37.   Sheikh I, Yasir M, Khan I, Bahdur S, Azam N, Jiffri E, Kamal M, Ashraf G, and Beg M. Lactoperoxidase immobilization on silver nanoparticles enhances its antimicrobial activity. (2018). Journal of Dairy Research. 85(4):460-464. DOI: 10.1017/S0022029918000730. Impact Factor 1.4 (2017).

38.   Yan-Hong Li, William Chi-Shing Tai, Khan I, Cheng Lu, Yao Lu, Wing-Yan Wong, Wood-Yee Chan, Wen-Luan Wendy Hsiao, Ge Lin. Toxicoproteomic assessment of liver responses following acute exposure to pyrrolizidine alkaloid in rat. (2018). Journal of environmental science and health part c-environmental carcinogenesis & ecotoxicology reviews, 36:2, 65-83. DOI: 10.1080/10590501.2018.1450186. Impact Factor 4.0 (2017).

39.   Ivo Ricardo de Seabra Rodrigues Dias, Simon Wing Fai Mok, Flora Gordillo Martínez, Khan I, W.L.Wendy Hsiao, Betty Yuen Kwan Law,  Vincent Kam Wai Wong and  Liang Liu. The calcium-induced regulation in the transcriptional and molecular circuitry of human inflammatory response and autoimmunity. Frontiers in Pharmacology. (Published: 8 Jan 2018). 8;8:962. DOI: 10.3389/fphar.2017.00962. Impact Factor 4.4 (2017).

40.   Khan TA, Youssri M. Ahmed, Mazin A. Zamzami, Saleh A. Mohamed, Khan I, Othman A.S. Baothman, Mohamed G. Mehanna, and Muhammad Yasir. Effect of atorvastatin on the gut microbiota of high fat diet-induced hypercholesterolemic rats. (2018). Scientific Reports. 8(1):662. DOI: 10.1038/s41598-017-19013-2. Impact Factor 5.3 (2017).

41.   Khan TA, Youssri M. Ahmed, Mazin A. Zamzami, Saleh A. Mohamed, Khan I, Othman A.S. Baothman, Mohamed G. Mehanna, and Muhammad Yasir. Atorvastatin Treatment Modulates the Gut Microbiota and Resilience in Abundance of Beneficial Taxa Among Hypercholesterolemic Patients. (published: 2 Feb 2018). OMICS: A Journal of Integrative Biology. 22(2):154-163. DOI: 10.1089/omi.2017.0130. Impact Factor 2.61 (2017).

42.   Guoxin H#, Khan I#, Xiaoang Li, Lei Chen, W.L. Wendy Hsiao. Ginsenosides Rb3 and Rd reduce polyps formation while reinstate the dysbiotic gut microbiota and the intestinal microenvironment in ApcMin/+ mice. (Published: 2 Oct 2017). Scientific Reports. 7: 12552. DOI:10.1038/s41598-017-12644-5. Impact Factor 5.3 (2016).

43.   Harakeh SM, Khan I, Almasaudi SB, Azhar EI, Al-Jaouni S, Niedzweicki A. Role of Nutrients and Phyto-compounds in the Modulation of Antimicrobial Resistance. Current Drug Metabolism. (2017). 18(9):858-867. doi: 10.2174/1389200218666170719095344. Impact Factor 2.98 (2016).

44.   Ullah Riaz; Yasir Muhammad; Khan I; Bibi Fehmida; Sohrab Sayed; Al-Ansari Ahmed; Al-Abbasi Fahad; Al-Sofyani Abdulmohsin; Azhar Esam. Comparative bacterial community analysis in relatively pristine and anthropogenically influenced mangrove ecosystems on the Red Sea. Canadian Journal of Microbiology. (2017). 63(8): 649-660. DOI: 10.1139/cjm-2016-0587. Impact Factor 1.55 (2016

45.   Khan I, Azhar E, Aymann A, Barbour E, Kumosani T, Didier Raoult, Yasir M,. Metagenomic analysis of antibiotics induced changes in gut microbiota of pregnant rat’s model. (Published: 28 Apr 2016). Frontiers in Pharmacology. 7: 14. DOI: 10.3389/fphar.2016.00104. Impact Factor 4.4 (2015).

46.   Khan I, Muhammad Yasir, Taha Kumosani, Aymn T. Abbas, Elie K. Barbour, Asif Ahmad Jiman-Fatani, Esam I. Azhar. Assessment of bacterial density, diversity, and antibiotic resistance-dissemination from multidrug-resistant Escherichia coli to rat’s gut microbiota in presence and absence of antibiotic treatment: a useful animal model for future investigations. (2016). International journal of applied research in veterinary medicine. 14(2). 170-184. Impact Factor 0.273 (2015).

47.   Khan I, Yasir M, Azhar EI, Kumosani T, Barbour EK, Bibi F, Kamal MA. Implication of Gut Microbiota in Human Health. (2014). CNS & Neurological Disorders - Drug Targets. 13(8):1325-33. Impact Factor 3.2 (2013).

48.   Harakeh SM, Khan I, Kumosani T, Barbour E, Almasaudi SB, Bahijri SM, Alfadul SM, Ajabnoor GM, Azhar EI. Gut microbiota: a contributing factor to obesity. (2016). Frontiers in Cellular and Infection Microbiology. 30; 6:95. DOI: 10.3389/fcimb.2016.00095. Impact Factor 5.3 (2015).

49.   Yasir M, Azhar E, Khan I, Bibi F, Randa Baabdullah, Ahmed K. Al–Ghamdi. Composition of soil microbiome and residue along elevation gradients in southwestern highlands of Saudi Arabia. (14 Mar 2015). BMC Microbiology. 15(65): 1-9. DOI: 10.1186/s12866-015-0398-4. Impact Factor 2.97 (2014).

50.   Syed Muhammad Hassan Shah, Syed Muhammad Mukarram Shah, Mohammad Nisar, Farhat Ali Khan, Mumtaz Ali, Khan I, Syed Muhammad Saifur Shah, Muhammad Siddique Afridi, Irshad Ali. (2012). Antimicrobial Activities of Medicinal Plants used in Folk Remedies in Pakistan. Journal of Pharmacy Research, 5(4), 2057-2060. ISSN: 0974-6943. Impact Factor 0.74.

1.     Khan, I*., Akmal, K.F., Chong, W.S., Venmathi Maran, B.A., Shah, M.D. (2023). Marine Biotechnology: A Frontier for the Discovery of Nutraceuticals, Energy, and Its Role in Meeting Twenty-First Century Food Demands. In: Shah, M.D., Ransangan, J., Venmathi Maran, B.A. (eds) Marine Biotechnology: Applications in Food, Drugs and Energy. Springer, Singapore.

2.     Ullah, R., Khan, I*. (2023). Biotechnological Utilization of the Marine Environment for Food, Drugs, and Energy. In: Shah, M.D., Ransangan, J., Venmathi Maran, B.A. (eds) Marine Biotechnology: Applications in Food, Drugs and Energy. Springer, Singapore.

3.     Khan, I*., Ullah, R., Ali, S., Shah, M.D. (2023). Bacterial Diversity in the Marine Environment and the Cutting-Edge Tools for Isolation, Identification and Characterization of the Marine Microbiome. In: Shah, M.D., Ransangan, J., Venmathi Maran, B.A. (eds) Marine Biotechnology: Applications in Food, Drugs and Energy. Springer, Singapore.

4.     Khan R, Shah L., and Khan I. Biotechnology in Pakistan: Past, Present, Future, Scope and Applications of Biotechnology in Pakistan. (2012). LAMBERT Academic Publishing. ISBN: 978-3-659-24381-3.