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YANG, YANG
Assistant Professor
Office: Room PP-R209e, Est. Seak Pai Van Praia Park , Rés-Do-Chão R, Coloane, Macau
E-mail: yangyang1@must.edu.mo
Dr. Yang Yang received her Bachelors’ degree from Shenyang Agricultural University in 2012 majoring in Biotechnology, and obtained her Ph.D degree in cell biology (neuroscience) from Zhejiang University in 2017. During her Ph.D, she visited Faculty of Medicine, University of Helsinki in Finland with a grant from the China Scholarship Council. And then continued her postdoctoral training in Helsinki for 3 years. She has participated in numerous research projects that were granted from both NCSF and Europe. Dr. Yang joined the School of Life anf Health Sciences at The Chinese University of Hong Kong (Shenzhen) as a lecturer from 2021, Jan until 2022, July. From 2022 Aug to present, she serves as Assistant Professor at Faculty of Medicine, Macau University of Science and Technology. Her main research interests include Mitochondrial protein homeostasis, Neurodegenerative disease modeling, protective mechanisms from effective Chinese medicine components and medical teaching innovation, positive learning etc.
Academic Qualification

2012.9 - 2017.6（Ph.D）Zhejiang University; School of Medicine 2015.11 - 2016.11（CSC joint Ph.D）University of Helsinki; Faculty of Medicine; 2008.9 - 2012.6（Bachelor）Shenyang Agricultural University; College of life science and technology

Teaching Area

Physiology; Biochemistry; Physiological anatomy

Research Area

Effects of Mitochondrial protein homeostasis on metabolism and neurological diseases； Neurodegenerative disease modeling and protective effects from Chinese medicine components; Medical teaching innovation, positive learning.

Working Experience

2022.9 - present: Assistant Professor, Faculty of Medicine, Macau University of Science and Technology; 2021.1- 2022.7: Lecturer, School of Medicine, The Chinese University of Hong Kong, Shenzhen; 2017.9-2020.8: Postdoctoral researcher, University of Helsinki; Faculty of Medicine; STEMM, RPU

Academic Publication (selected)

1. Döhla, J., Kuuluvainen, E., Gebert, N., Amaral, A., Englund, J. I., Gopalakrishnan, S., Konovalova, S., Nieminen, A. I., Salminen, E. S., Torregrosa Munumer, R., Ahlqvist, K., Yang, Y., Bui, H., Otonkoski, T., Käkelä, R., Hietakangas, V., Tyynismaa, H., Ori, A. & Katajisto, P. Metabolic determination of cell fate through selective inheritance of mitochondria, Nature Cell Biology. Feb 2022, 24, 2, p. 148-+ 27 p.

2. G Liu; C Jiang; X Lin; Y Yang. Point‐of‐care detection of cytokines in cytokine storm management and beyond: Significance and challenges. View, 20210003.

3.Long B; Siqi H; Wenchao X; Liang L; Yang Y; Robertus Wahyu N; Yimin F; Orlando R. Self-assembled networks of short and long chitin nanoparticles for oil/water interfacial super-stabilization, ACS Sustainable Chem. Eng. 2019, 7, 7, 6497–6511. 4.Konovalova S, Liu X, Manjunath P, Baral S, Neupane N, Hilander T, Yang Y, Balboa D, Terzioglu M, Euro L, Varjosalo M & Tyynismaa H. Redox regulation of GRPEL2 nucleotide exchange factor for mitochondrial HSP70 chaperone Oct 2018, In: Redox biology. 19, p. 37-45 9 p.

5.Cooper. H*, Yang Y*, Ylikallio. E, Khairullin R, Woldegebriel R, Lin. K, Euro. L, Palin. E, Wolf. A, Trokovic R, Isohanni. P, Kaakkola. S, Auranen. M, Lonnqvist. T, Wanrooij. S, Tyynismaa. H. ATPase-deficient mitochondrial inner membrane protein ATAD3A disturbs mitochondrial dynamics in dominant hereditary spastic paraplegia. Hum Mol Genet. 2017 Jan 31. doi: 10.1093/hmg/ddx042. (Co-first author)

6.Yang Y, Hu Z, Du X, Davies H, Huo X, Fang M. miR-16 and Fluoxetine Both Reverse Autophagic and Apoptotic Change in Chronic Unpredictable Mild Stress Model Rats. Front Neurosci. 2017 Jul 25;11:428. doi: 10.3389/fnins.2017.00428. eCollection 2017. 7.Yang Y, Gao K, Hu Z, Li W, Davies H, Ling S, Rudd JA, Fang M. Autophagy upregulation and apoptosis downregulation in DAHP and triptolide treated cerebral ischemia. Mediators Inflamm. 2015; 2015:120198.

8.Yang Y, Marong Fang, Xiaoxue Du, Zhiying Hu. Lucky gene 5-HTTLPR and postpartum depression: A systematic review. Neuroendocrinology Letters Volume 38 No. 5 2017. 9.Li W, Yang Y, Hu Z, Ling S, Fang M. Neuroprotective effects of DAHP and Triptolide in focal cerebral ischemia via apoptosis inhibition and PI3K/Akt/mTOR pathway activation. Front Neuroanat. 2015 Apr 22; 9:48.

10.Hu Z, Yang Y, Gao K, Rudd JA, Fang M. Ovarian hormones ameliorate memory impairment, cholinergic deficit, neuronal apoptosis and astrogliosis in a rat model of Alzheimer's disease. Exp Ther Med. 2016 Jan;

11(1):89-97. 11.Du X, Huo X, Yang Y, Hu Z, Botchway BOA, Jiang Y, Fang M. miR-124 downregulates BACE 1 and alters autophagy in APP/PS1 transgenic mice. Toxicol Lett. 2017 Oct 5;280:195-205.

12.Bai S, Hu Z, Yang Y, Yin Y, Li W, Wu L, Fang M. Anti-Inflammatory and Neuroprotective Effects of Triptolide via the NF-κB Signaling Pathway in a Rat MCAO Model. Anat Rec (Hoboken). 2016 Feb;299(2):256-66. doi: 10.1002/ar.23293.

13.Liu X, Zhang Y, Yang Y, Lin J, Huo X, Du X, Botchway BOA, Fang M. Therapeutic Effect of Curcumin and Methylprednisolone in the Rat Spinal Cord Injury. Anat Rec (Hoboken). 2018 Apr;301(4):686-696. doi: 10.1002/ar.23729. Epub 2017 Nov 28.

14.Qin Y, Hu W, Yang Y, Hu Z, Li W, Fang M. Neuroprotective Effect of DAHP via Antiapoptosis in Cerebral Ischemia. Behav Neurol. 2018 Jun 19;2018:5050469. doi: 10.1155/2018/5050469. eCollection 2018.

15.Hu Z, Du X, Yang Y, Botchway BOA, Fang M. Progesterone and fluoxetine treatments of postpartum depressive-like behavior in rat model. Cell Biol Int. 2019 May;43(5):539-552. doi: 10.1002/cbin.11123. Epub 2019 Mar 19

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