黃耀南
助理教授(生物化學)及哈佛HMX線上課程
辦公室 擎天匯校區 PP-R209d
電子信箱 inwong@must.edu.mo
黃耀南博士自2019年7月起擔任澳門科技大學醫學院助理教授。他於2006年從北京師範大學獲得生物學學士學位。隨後於2007年在謝菲爾德大學分子醫學(遺傳學)領域獲得碩士學位,並以第一名的成績畢業。2012年,他在謝菲爾德大學以畢業論文毋須作任何修改的成績完成答辯並獲得醫學博士學位。在加入澳門科技大學之前,黃博士曾在謝菲爾德大學和牛津大學擔任博士後研究員。期間,他運用蛋白質生物化學、結構生物學、細胞生物學和蛋白質組學等先進技術,成功發現了病毒和人體中新的DNA複製和修復因子。這些研究成果已發表在Nucleic Acid Res., eLife, Sci. Rep.等知名期刊上。

目前,黃博士專注於尋找用於治療癌症、神經退行性疾病、免疫調節,並具有潛在臨床應用價值的天然化合物,同時探究其作用的分子機理。他最近的研究成果已發表在Pharmacol. Res., Food Chem.:X and Int. J. Biol. Macromol.等期刊上。

最近,他被澳門特區政府委任為人才發展委員會「大健康」產業專責小組成員。
學歷

2012 年:英國謝菲爾德大學醫學博士學位 (Outright Pass)

2007 年:英國謝菲爾德大學分子醫學(遺傳)碩士學位 (Distinction; Rank: 1st)

2006 年:北京師範大學生物學學士學位


教學領域

Biochemistry; HMX programme coordinator; Medical Ethics, Humanities and Law course coordinator; MBBS year 1-5 system block, clerkship coordinator

研究領域

1.  Wong Io Nam (PI), Sookja Kim Chung (Co-I), Molecular mechanism of Caulerpa sulfated polysaccharides on immunometabolic reprogramming by targeting COX-2-induced ferroptosis, FDCT-NSFC 2022-2024, MOP$ 1,600,000. Project No. 0069/2021/AFJ.

2.    Wong Io Nam (PI), Characterization of potential novel pro- and anti-viral host factors from proximity-dependent biotin idenfication (BioID) screen for SV40 host restriction factor FAM111A, FRG 2022-2023, MOP $100,000. Project No. FRG-22-022-FMD.

3.     Zhang Kang (PI), Wong Io Nam (Co-I), Simon Wing Fai Mok (Co-I), Induction of conjunctival stem cells into limbal-like stem cells and corneal reconstruction, FDCT-NSFC 2020-2023, MOP$2,000,000. Project No. 0007/2020/AFJ.

4.     Simon Wing Fai Mok (PI), Wong Io Nam (Co-I), Vincent Kam Wai Wong (Co-I), To unveil the modulatory role of p53 aggregates in the progression of Rheumatoid Arthritis, FDCT 2023-2025, MOP $425,000. Project No. 0037/2022/ITP.

5.      Olivia Monteiro (PI), Wong Io Nam (Co-I), Brian Tomlinson (Co-I), Christopher Wai Kei Lam (Co-I), Effects of Sinopharm BBIBP-CorV and BioNTech mRNA primary vaccine series with homologous and heterologous boosters against SARS-CoV2 variants of concern in a local population in Macao. FDCT 2022-2023, MOP $644,000. Project No. 0106/2021/A.



工作經歷

20197月至今:澳門科技大學助理教授 

2013–2019年:英國牛津大學博士後研究員 

2012–2013年:英國謝菲爾德大學博士後研究員 

2007–2008年:英國謝菲爾德大學實驗室技術員 


學術出版物(精選)

1.        Wong IN, Monteiro O, Baptista-Hon DT, Wang K, Lu W, Sun Z, Nie S, Yin Y, Leveraging foundation and large language models in medical artificial intelligence (2024). Chin Med J. DOI:10.1097/ CM9.0000000000003302.

2.        Xia X, Wu Y, Chen Z, Du D, Chen X, Zhang R, Yan J, Wong IN*, Huang R, An edible green algae polysaccharide CRVP from Caulerpa racemosa var. peltate induced apoptosis of liver cancer cells Hepa1-6 by regulating glutathione metabolism. Food Sci Hum Wellness (2024). DOI: 10.26599/FSHW.2024.9250300. (* co-corresponding author)

3.        Wang XX, Ji X, Lin J, Wong IN, Lo HH, Wang J, Qu L, Wong VKW, Chung SK, Law BYK, GPCR-mediated natural products and compounds: Potential therapeutic targets for the treatment of neurological diseases (2024). Pharmacol Res., 208: 107395.

4.        Qin B, Fu S, Xu X, Yang J, Wang Y, Wang L, Huang B, Zhang J, Wu W, Lu H, Law BYK, Wang N, Wong IN*, Wong VKW, Far-infrared radiation and its therapeutic parameters: A superior alternative for future regenerative medicine? (2024). Pharmacol Res., 208 : 107349. (* co-corresponding author)

5.        Zeng J, Liu J, Zhao N, Wong IN*, Huang R, Caulerpa chemnitzia polysaccharide exerts immunomodulatory activity in macrophages by mediating the succinate/PHD2/HIF-1α/IL-1β pathway, (2024). Int J Biol Macromol., 2024 Oct: 134450. (* co-corresponding author)

6.        Yu H, Xie Y, Lan L, Ma S, Mok SWF, Wong IN, Wang Y, Zhong G, Yuan L, Zhao H, Macrae VE, He S, Chen G, Zhu D, Sirt7 protects against vascular calcification via modulation of reactive oxygen species and senescence of vascular smooth muscle cells (2024). Free Radic Biol Med., 223: 30-41.

7.        Xia X, Wu Y, Chen Z, Du D, Chen X, Zhang R, Yan J, Wong IN*, Huang R, Colon cancer inhibitory properties of Caulerpa lentillifera polysaccharide and its molecular mechanisms based on three-dimensional cell culture model (2024). Int J Biol Macromol., 2024 Apr 12:131574. (* co-corresponding author)

8.        Wijesekara T, Huang R, Wong IN*, Xu B, Insights into immunoregulatory effects of bioactive polysaccharides derived from seaweeds through gut microbiota (2024). Food Biosci., 58: 103800. (* co-corresponding author)

9.        Yang J, Liu J, Kuang W, Lin Y, Zhong S, Kraithong S, Zhang X, Wong IN*, Huang R. Structural characterization and ferroptosis-related immunomodulatory of a novel exopolysaccharide isolated from marine fungus Aspergillus medius (2024). Int J Biol Macromol., 2024 Mar 6:130703. (* co-corresponding author)

10.    Wang HM, Lai HJ, Wu AG, Tong Y, Song LL, Lo HH, Wong IN, Wong VKW, Law BYK. Melanogenic effects of 5-demethylnobiletin on mouse model of chemical-induced vitiligo (2024). J. Funct. Foods, 112: 105962.

11.    Zeng J, Lin Q, Xu J, Xu B, Wong IN*, Huang R, Oligosaccharides Preparation from Caulerpa racemosa var peltate with Enzymatic Hydrolysis and Its Mechanism of Immunomodulatory Activity (2024).食品科學. (* co-corresponding author)

12.    Tam HH, Zhu D, Ho SSK, Vong HW, Wong VKW, Mok SWF, Wong IN. Potential enhancement of post-stroke angiogenic response by targeting the oligomeric aggregation of p53 protein (2023). Front. Cell. Neurosci., 17:1193362.

13.    Qiu C, Chan JTW, Zhang DW, Wong IN, Zeng Y, Law BYK, Mok SWF, Dias IRDSR, Liu W, Liu L, Wong VKW. The potential development of drug-resistance in rheumatoid arthritis patients identified with p53 mutations (2023). Genes Dis., 10(6):2252-2255.

14.    Wu Y, Liu J, Hao H, Hu L, Zhang X, Luo L, Zeng J, Zhang W, Wong IN, Huang R. A new polysaccharide from Caulerpa chemnitzia induces molecular shifts of immunomodulation on macrophages RAW264.7 (2022). Food Chem.:X, 14: 100313.

15.    Yang L, Liu J, Xia X, Wong IN, Chung SK, EI-Seedi HR, Wang B, Hunag R. Sulfated heteropolysaccharides from Undaria pinnatifida: Structural characterization and transcript-metabolite profiling of immunostimulatory effects on RAW264. 7 cells (2022). Food Chem.: X, 13:100264.

16.    Xia X, Hao H, Zhang X, Wong IN, Chung SK, Chen Z, Xu B, Huang R. Immunomodulatory sulfated polysaccharides from Caulerpa racemosa var. peltata induces metabolic shifts in NF-κB signaling pathway in RAW 264.7 macrophages (2021). Int J Biol Macromol., 182:321-332.

17.    Monteiro O, Bhaskar A, Wong IN, Ng AKM, Baptista-Hon DT. Teaching bioelectricity and neurophysiology to medical students using LabAXON simulations (2021). Adv Physiol Educ., 45(4):702-708.

18.    Wong IN, Neo JPS, Oehler J, Schafhauser S, Osman F, Carr SB, Whitby MC (2019). The Fml1-MHF complex suppresses inter-fork strand annealing in fission yeast. eLife, 8, e49784.

19.    Morrow CA, Nguyen MO, Fower A, Wong IN, Osman F, Bryer C, Whity MC (2017). Inter-fork strand annealing causes genomic deletions during the termination of DNA replication. eLife, 6, e25490.

20.    Wong IN, Sayers JR, Sanders CM (2016). Bacteriophage T5 gene D10 encodes a branch-migration protein. Scientific Reports, 6, 39414.

21.    Wong IN, Sayers JR, Sanders CM (2013). Characterization of an unusual bipolar helicase encoded by bacteriophage T5. Nucleic Acids Res, 41(8), 4587-600.


書籍
專利
專業認證和獎項

2008年–2012年:英國謝菲爾德大學博士獎學金 

2006年–2007年:澳門高等教育局研究生獎學金 

2002年–2006年:澳門教育暨青年局大專獎學金 

2002 年:澳門蓮花獎 

1999 年:澳門總督獎 


專業協會會員資格

澳門科技大學學術誠信委員會成員 

澳門科技大學學生紀律獎懲委員會委員

澳門科技大學跨學科教學實驗室委員會委員 

澳門科技大學醫學院內外全科學士學位課程遴選委會成員 

澳門科技大學醫學院內外全科學士學位課程評估委員會成員 

澳門特區政府人才發展委員會大健康產業專責小組成員