Currently, Dr. Wong is focused on identifying natural compounds with potential clinical applications in cancer treatment, neurodegenerative diseases, and immunoregulation, while investigating the underlying mechanisms. His recent discoveries have been published in journals like Pharmacol. Res., Food Chem.:X and Int. J. Biol. Macromol.
Most recently, he was appointed as a member of the talent development committee's task force on “Big Health” by the Macao SAR government.
2012: PhD in Medicine, University of Sheffield (Outright Pass)
2007: MSc in Molecular Medicine (Genetics) with Distinction (Rank: 1st), University of Sheffield
2006: BSc in Biology, Beijing Normal University
Biochemistry; HMX programme coordinator; Medical Ethics, Humanities and Law course coordinator; MBBS year 1-5 system block, clerkship coordinator
1. Molecular mechanism of Caulerpa sulfated polysaccharides on immunometabolic reprogramming by targeting COX-2-induced ferroptosis, FDCT-NSFC Project No. 0069/2021/AFJ.
2. Characterization of potential novel pro- and anti-viral host factors from proximity-dependent biotin idenfication (BioID) screen for SV40 host restriction factor FAM111A, FRG Project No. FRG-22-022-FMD.
3. Induction of conjunctival stem cells into limbal-like stem cells and corneal reconstruction, FDCT-NSFC Project No. 0007/2020/AFJ.
4. To unveil the modulatory role of p53 aggregates in the progression of Rheumatoid Arthritis, FDCT Project No. 0037/2022/ITP.
5. Effects of Sinopharm BBIBP-CorV and BioNTech mRNA primary vaccine series with homologous and heterologous boosters against SARS-CoV2 variants of concern in a local population in Macao. FDCT Project No. 0106/2021/A.
Jul 2019 – present: Assistant Professor, Macau University of Science and Technology
2013 – 2019: Postdoctoral Research Fellow, University of Oxford
2012 – 2013: Postdoctoral Research Fellow, University of Sheffield
2007 – 2008: Graduate Technician, University of Sheffield
1. Wong IN, Monteiro O, Baptista-Hon DT, Wang K, Lu W, Sun Z, Nie S, Yin Y, Leveraging foundation and large language models in medical artificial intelligence (2024). Chin Med J. DOI:10.1097/ CM9.0000000000003302.
2. Xia X, Wu Y, Chen Z, Du D, Chen X, Zhang R, Yan J, Wong IN*, Huang R, An edible green algae polysaccharide CRVP from Caulerpa racemosa var. peltate induced apoptosis of liver cancer cells Hepa1-6 by regulating glutathione metabolism. Food Sci Hum Wellness (2024). DOI: 10.26599/FSHW.2024.9250300. (* co-corresponding author)
3. Wang XX, Ji X, Lin J, Wong IN, Lo HH, Wang J, Qu L, Wong VKW, Chung SK, Law BYK, GPCR-mediated natural products and compounds: Potential therapeutic targets for the treatment of neurological diseases (2024). Pharmacol Res., 208: 107395.
4. Qin B, Fu S, Xu X, Yang J, Wang Y, Wang L, Huang B, Zhang J, Wu W, Lu H, Law BYK, Wang N, Wong IN*, Wong VKW, Far-infrared radiation and its therapeutic parameters: A superior alternative for future regenerative medicine? (2024). Pharmacol Res., 208 : 107349. (* co-corresponding author)
5. Zeng J, Liu J, Zhao N, Wong IN*, Huang R, Caulerpa chemnitzia polysaccharide exerts immunomodulatory activity in macrophages by mediating the succinate/PHD2/HIF-1α/IL-1β pathway, (2024). Int J Biol Macromol., 2024 Oct: 134450. (* co-corresponding author)
6. Yu H, Xie Y, Lan L, Ma S, Mok SWF, Wong IN, Wang Y, Zhong G, Yuan L, Zhao H, Macrae VE, He S, Chen G, Zhu D, Sirt7 protects against vascular calcification via modulation of reactive oxygen species and senescence of vascular smooth muscle cells (2024). Free Radic Biol Med., 223: 30-41.
7. Xia X, Wu Y, Chen Z, Du D, Chen X, Zhang R, Yan J, Wong IN*, Huang R, Colon cancer inhibitory properties of Caulerpa lentillifera polysaccharide and its molecular mechanisms based on three-dimensional cell culture model (2024). Int J Biol Macromol., 2024 Apr 12:131574. (* co-corresponding author)
8. Wijesekara T, Huang R, Wong IN*, Xu B, Insights into immunoregulatory effects of bioactive polysaccharides derived from seaweeds through gut microbiota (2024). Food Biosci., 58: 103800. (* co-corresponding author)
9. Yang J, Liu J, Kuang W, Lin Y, Zhong S, Kraithong S, Zhang X, Wong IN*, Huang R. Structural characterization and ferroptosis-related immunomodulatory of a novel exopolysaccharide isolated from marine fungus Aspergillus medius (2024). Int J Biol Macromol., 2024 Mar 6:130703. (* co-corresponding author)
10. Wang HM, Lai HJ, Wu AG, Tong Y, Song LL, Lo HH, Wong IN, Wong VKW, Law BYK. Melanogenic effects of 5-demethylnobiletin on mouse model of chemical-induced vitiligo (2024). J. Funct. Foods, 112: 105962.
11. Zeng J, Lin Q, Xu J, Xu B, Wong IN*, Huang R, Oligosaccharides Preparation from Caulerpa racemosa var peltate with Enzymatic Hydrolysis and Its Mechanism of Immunomodulatory Activity (2024).食品科學. (* co-corresponding author)
12. Tam HH, Zhu D, Ho SSK, Vong HW, Wong VKW, Mok SWF, Wong IN. Potential enhancement of post-stroke angiogenic response by targeting the oligomeric aggregation of p53 protein (2023). Front. Cell. Neurosci., 17:1193362.
13. Qiu C, Chan JTW, Zhang DW, Wong IN, Zeng Y, Law BYK, Mok SWF, Dias IRDSR, Liu W, Liu L, Wong VKW. The potential development of drug-resistance in rheumatoid arthritis patients identified with p53 mutations (2023). Genes Dis., 10(6):2252-2255.
14. Wu Y, Liu J, Hao H, Hu L, Zhang X, Luo L, Zeng J, Zhang W, Wong IN, Huang R. A new polysaccharide from Caulerpa chemnitzia induces molecular shifts of immunomodulation on macrophages RAW264.7 (2022). Food Chem.:X, 14: 100313.
15. Yang L, Liu J, Xia X, Wong IN, Chung SK, EI-Seedi HR, Wang B, Hunag R. Sulfated heteropolysaccharides from Undaria pinnatifida: Structural characterization and transcript-metabolite profiling of immunostimulatory effects on RAW264. 7 cells (2022). Food Chem.: X, 13:100264.
16. Xia X, Hao H, Zhang X, Wong IN, Chung SK, Chen Z, Xu B, Huang R. Immunomodulatory sulfated polysaccharides from Caulerpa racemosa var. peltata induces metabolic shifts in NF-κB signaling pathway in RAW 264.7 macrophages (2021). Int J Biol Macromol., 182:321-332.
17. Monteiro O, Bhaskar A, Wong IN, Ng AKM, Baptista-Hon DT. Teaching bioelectricity and neurophysiology to medical students using LabAXON simulations (2021). Adv Physiol Educ., 45(4):702-708.
18. Wong IN, Neo JPS, Oehler J, Schafhauser S, Osman F, Carr SB, Whitby MC (2019). The Fml1-MHF complex suppresses inter-fork strand annealing in fission yeast. eLife, 8, e49784.
19. Morrow CA, Nguyen MO, Fower A, Wong IN, Osman F, Bryer C, Whity MC (2017). Inter-fork strand annealing causes genomic deletions during the termination of DNA replication. eLife, 6, e25490.
20. Wong IN, Sayers JR, Sanders CM (2016). Bacteriophage T5 gene D10 encodes a branch-migration protein. Scientific Reports, 6, 39414.
21. Wong IN, Sayers JR, Sanders CM (2013). Characterization of an unusual bipolar helicase encoded by bacteriophage T5. Nucleic Acids Res, 41(8), 4587-600.
2008-2012:Sheffield University Doctoral Fellowship
2006-2007: Macau Postgraduate Scholarship
2002-2006: Macau Tertiary Scholarship
2002: Macau Lotus award
1999: Macau Governor’s award
Member of academic integrity committee (MUST)
Member of student disciplinary committee (MUST)
Member of interdisciplinary teaching laboratory committee (MUST)
Member of selection committee for MBBS programme
Member of academic assessment committee for MBBS programme
Member of the task force on “Big Health” of the talent development committee by Macao SAR government
