目前，黄博士专注于寻找用于治疗癌症、神经退行性疾病、免疫调节，并具有潜在临床应用价值的天然化合物，同时探究其作用的分子机理。同时，他亦探索医学人工智能的临床应用，包括建立人类全周期生物钟模型，以加深对昼夜节律对疾病与治疗影响的理解，并研发用于临床决策支持的AI工具。透过结合天然产物研究与计算及AI方法，加速从分子水平到临床落地的转化。其近期成果发表于Nat. Med., Trends Mol. Med., J. Transl. Med., Chin. Med. J., Pharmacol. Res., Biomark. Res., Food Chem.:X and Int. J. Biol. Macromol.等期刊上。此外，他被任命为澳门特区政府委任为生命科学道德委员会成员，亦曾任人才发展委员会「大健康」产业专责小组成员。
2012年6月：英国谢菲尔德大学医学博士学位 (Outright Pass)
2007年11月：英国谢菲尔德大学分子医学(遗传)硕士学位 (Distinction; Rank: 1st)
2006年7月：北京师范大学生物学学士学位
Biochemistry; HMX programme coordinator; Medical Ethics, Humanities and Law course coordinator; MBBS year 1-5 system block, clerkship coordinator
1. 2025年5月–2028年5月: FDCT, Wong Io Nam (PI), 总状蕨藻硫酸多糖介导DNA损伤修复途径提高微卫星稳定型（MSS）胃癌治疗效果的机制研究与应用探索, 项目编号 0133/2024/RIA2, MOP$ 1,700,900
2. 2021年9月–2024年9月: FDCT-NSFC, Wong Io Nam (PI), 蕨藻硫酸多糖靶向COX-2介导的铁死亡重塑免疫代谢的分子机制研究, 项目编号 0069/2021/AFJ, MOP$ 1,600,000
3. 2022年2月–2023年8月: FRG, Wong Io Nam (PI), 利用BioID邻位生物素标记的方法去探究与SV40宿主抑制因子FAM111A相互作用的潜在新的促病毒和抗病毒因子之特性, 项目编号 FRG-22-022-FMD, MOP $100,000
4. 2024年6月–2027年6月: FDCT-AKP, Paul Kwong-Hang Tam (PI), Chen Yan (Co-PI), Wong Io Nam (Member), 结合再生医学,多组学及人工智能平台开展改善慢性肝病纤维化的标靶发现及精准干预新诊疗, 项目编号 0011/2023/AKP, MOP$ 11,917,000
5. 2022年12月–2025年6月: FDCT-ITP, Simon Wing Fai Mok (PI), Wong Io Nam (Co-PI), Vincent Kam Wai Wong (Co-PI), 揭示p53聚合体在类风湿性关节炎病理发展中的调节作用, 项目编号 0037/2022/ITP, MOP $425,000
6. 2022年4月– 2025年4月: FDCT, Olivia Monteiro (PI), Wong Io Nam (Co-PI), Brian Tomlinson (Co-I), Christopher Wai Kei Lam (Co-I), 研究国药灭活疫苗 BBIBP-CorV 和 BioNTech mRNA 疫苗初种系列及同源与异源加强剂在澳门地区人群中对新冠肺炎病毒株的有效性, 项目编号 0106/2021/A, MOP $644,000
7. 2020年9月–2023年9月: FDCT-NSFC, Zhang Kang (PI), Wong Io Nam (Co-PI), Simon Wing Fai Mok (Co-I), 结膜干细胞转化类角膜缘干细胞与角膜重建, 项目编号0007/2020/AFJ, MOP$ 2,000,000
2019年7月至今：澳门科技大学助理教授
2013年9月–2019年5月：英国牛津大学博士后研究员
2012年5月–2013年9月：英国谢菲尔德大学博士后研究员
2007年2月–2008年8月：英国谢菲尔德大学实验室技术员
1. Li G, Cheng L, Wong IN*, Yin Y, Chen J, Liu L, Zhang K. Predicting healthspan and disease risks through biological age (2025). Trends Mol Med, DOI: 10.1016/j.molmed.2025.10.006. (*first author, IF 13.8, SCI Q1)
2. Zhong J, Chung SK, Han X, Huang R, Xu B, Wong IN (2025). Front Pharmacol, DOI: 10.3389/fphar.2025.1682025. (Corresponding author, IF 4.8, SCI Q1)
3. Wang K, Liu F, Wu W, Hu H, Shen X, Wang M, Li G, Zeng F, Liu L, Wong IN, Liu S, Zou Z, Li B, Li J, Huang X, Jin S, Li Z, Xu H, Chen G, Chen X, Zhu Y, Li P, Feng Z, Wang W. A full life cycle biological clock based on routine clinical data and its impact in health and diseases (2025). Nat Med, DOI: 10.1038/s41591-025-04006-w. (second author, IF 50.0, SCI Q1)
4. Liu F, Niu Y, Zhang Q, Kang K, Dong Z, Wong IN, Cheng L, Li T, Duan L, Li K, Li G, Hou TW, Fok M, Luo Hu, Chen X, Zhang K, Yin Y. A foundational architecture for AI agents in healthcare (2025). Cell Rep Med, DOI: 10.1016/j.xcrm.2025.102374. (sixth author, IF 10.6, SCI Q1)
5. Huang C, Xiao Y, Xu D, Wong IN, Patil NG, Chen J, Zhang K, Hu W, Zhang J, Ding S, Kuang M, Xiao H, Feng X. Developing a Student-Centred Curriculum: Insights from Anaesthetic Placement Experiences for Co-Designing in China’s Greater Bay Area (2025). Adv medical educ pract., 16, 1695-1704. (second author, IF 1.7, ESCI Q2)
6. Yang L, Mok SWF, Li HH, Wong IN*, Yang LJ. DDX27 in cancer: molecular mechanisms, clinical implications, and therapeutic potential (2025). J Transl Med, 23, 971. (* corresponding author, IF 7.5, SCI Q1)
7. Xia X, Wu Y, Chen Z, Du D, Chen X, Zhang R, Yan J, Wong IN*, Huang R, An edible green algae polysaccharide CRVP from Caulerpa racemosa var. peltate induced apoptosis of liver cancer cells Hepa1-6 by regulating glutathione metabolism (2025). Food Sci Hum Wellness, DOI: 10.26599/FSHW.2024.9250300. (* corresponding author, IF 5.6, SCI Q1)
8. Qu L, Tang Y, Wu J, Yun X, Lo HH, Song L, Wang X, Wang H, Zhang R, Liu M, Wang C, Ng JPL, Fu X, Wong IN*, Wong VKW, Law BYK, FBXL16: a new regulator of neuroinflammation and cognition in Alzheimer’s disease through the ubiquitination-dependent degradation of amyloid precursor protein (2024). Biomark Res., 12, 144. (* corresponding author, IF 9.5, SCI Q1)
9. Wong IN, Monteiro O, Baptista-Hon DT, Wang K, Lu W, Sun Z, Nie S, Yin Y, Leveraging foundation and large language models in medical artificial intelligence (2024). Chin Med J. DOI:10.1097/ CM9.0000000000003302. (first author, IF 7.5, SCI Q1)
10. Zeng J, Liu J, Zhao N, Wong IN*, Huang R, Caulerpa chemnitzia polysaccharide exerts immunomodulatory activity in macrophages by mediating the succinate/PHD2/HIF-1α/IL-1β pathway, (2024). Int J Biol Macromol., 2024 Oct: 134450. (* corresponding author, IF 7.7, SCI Q1)
11. Qin B, Fu S, Xu X, Yang J, Wang Y, Wang L, Huang B, Zhang J, Wu W, Lu H, Law BYK, Wang N, Wong IN*, Wong VKW, Far-infrared radiation and its therapeutic parameters: A superior alternative for future regenerative medicine? (2024). Pharmacol Res., 208 : 107349. (* corresponding author, IF 9.1, SCI Q1)
12. Wang XX, Ji X, Lin J, Wong IN, Lo HH, Wang J, Qu L, Wong VKW, Chung SK, Law BYK, GPCR-mediated natural products and compounds: Potential therapeutic targets for the treatment of neurological diseases (2024). Pharmacol Res., 208: 107395. (second author, IF 9.1, SCI Q1)
13. Zhang J, Tang Y, Feng S, Wong IN*, Guo Y, Zhang J, Chen J, Yang D, Zhang K, Yao W, Li R, Bai Y, Ding S, Kuang M, Xiao H, Xu D, Collaborative Teaching and Curricular Integration in Pre-Intern Clinical Placements: Insights from the Greater Bay Area (2024). Adv medical educ pract., 15, 1027-1037. (* first author, IF 1.8, ESCI Q2)
14. Yu H, Xie Y, Lan L, Ma S, Mok SWF, Wong IN, Wang Y, Zhong G, Yuan L, Zhao H, Macrae VE, He S, Chen G, Zhu D, Sirt7 protects against vascular calcification via modulation of reactive oxygen species and senescence of vascular smooth muscle cells (2024). Free Radic Biol Med., 223: 30-41. (fourth author, IF 7.1, SCI Q1)
15. Xia X, Wu Y, Chen Z, Du D, Chen X, Zhang R, Yan J, Wong IN*, Huang R, Colon cancer inhibitory properties of Caulerpa lentillifera polysaccharide and its molecular mechanisms based on three-dimensional cell culture model (2024). Int J Biol Macromol., 2024 Apr 12:131574. (* corresponding author, IF 7.7, SCI Q1)
16. Yang J, Liu J, Kuang W, Lin Y, Zhong S, Kraithong S, Zhang X, Wong IN*, Huang R. Structural characterization and ferroptosis-related immunomodulatory of a novel exopolysaccharide isolated from marine fungus Aspergillus medius (2024). Int J Biol Macromol., 2024 Mar 6:130703. (* corresponding author, IF 7.7, SCI Q1)
17. Wijesekara T, Huang R, Wong IN*, Xu B, Insights into immunoregulatory effects of bioactive polysaccharides derived from seaweeds through gut microbiota (2024). Food Biosci., 58: 103800. (* corresponding author, IF 4.8, SCI Q1)
18. Wang HM, Lai HJ, Wu AG, Tong Y, Song LL, Lo HH, Wong IN, Wong VKW, Law BYK. Melanogenic effects of 5-demethylnobiletin on mouse model of chemical-induced vitiligo (2024). J. Funct. Foods, 112: 105962. (seventh author, IF 3.8, SCI Q2)
19. Zeng J, Lin Q, Xu J, Xu B, Wong IN*, Huang R, Oligosaccharides Preparation from Caulerpa racemosa var peltate with Enzymatic Hydrolysis and Its Mechanism of Immunomodulatory Activity (2024).食品科学. (* corresponding author, IF 2.1, CSCD)
20. Qiu C, Chan JTW, Zhang DW, Wong IN, Zeng Y, Law BYK, Mok SWF, Dias IRDSR, Liu W, Liu L, Wong VKW. The potential development of drug-resistance in rheumatoid arthritis patients identified with p53 mutations (2023). Genes Dis., 10(6):2252-2255. (second author, IF 6.9, SCI Q1)
21. Tam HH, Zhu D, Ho SSK, Vong HW, Wong VKW, Mok SWF, Wong IN. Potential enhancement of post-stroke angiogenic response by targeting the oligomeric aggregation of p53 protein (2023). Front. Cell. Neurosci., 17:1193362. (corresponding author, IF 4.2, SCI Q2)
22. Wu Y, Liu J, Hao H, Hu L, Zhang X, Luo L, Zeng J, Zhang W, Wong IN, Huang R. A new polysaccharide from Caulerpa chemnitzia induces molecular shifts of immunomodulation on macrophages RAW264.7 (2022). Food Chem.:X, 14: 100313. (eighth author, IF 6.5, SCI Q2)
23. Yang L, Liu J, Xia X, Wong IN, Chung SK, EI-Seedi HR, Wang B, Hunag R. Sulfated heteropolysaccharides from Undaria pinnatifida: Structural characterization and transcript-metabolite profiling of immunostimulatory effects on RAW264. 7 cells (2022). Food Chem.: X, 13:100264. (third author, IF 6.5, SCI Q1)
24. Xia X, Hao H, Zhang X, Wong IN, Chung SK, Chen Z, Xu B, Huang R. Immunomodulatory sulfated polysaccharides from Caulerpa racemosa var. peltata induces metabolic shifts in NF-κB signaling pathway in RAW 264.7 macrophages (2021). Int J Biol Macromol., 182:321-332. (third author, IF 7.7, SCI Q1)
25. Monteiro O, Bhaskar A, Wong IN, Ng AKM, Baptista-Hon DT. Teaching bioelectricity and neurophysiology to medical students using LabAXON simulations (2021). Adv Physiol Educ., 45(4):702-708. (third author, IF 1.7, SCI Q2)
26. Wong IN, Neo JPS, Oehler J, Schafhauser S, Osman F, Carr SB, Whitby MC (2019). The Fml1-MHF complex suppresses inter-fork strand annealing in fission yeast. eLife, 8, e49784. (first author, IF 6.4, SCI Q1)
27. Morrow CA, Nguyen MO, Fower A, Wong IN, Osman F, Bryer C, Whity MC (2017). Inter-fork strand annealing causes genomic deletions during the termination of DNA replication. eLife, 6, e25490. (fourth author, IF 6.4, SCI Q1)
28. Wong IN, Sayers JR, Sanders CM (2016). Bacteriophage T5 gene D10 encodes a branch-migration protein. Scientific Reports, 6, 39414. (first author, IF 3.8, SCI Q1)
29. Wong IN, Sayers JR, Sanders CM (2013). Characterization of an unusual bipolar helicase encoded by bacteriophage T5. Nucleic Acids Res, 41(8), 4587-600. (first author, IF 16.7, SCI Q1)
黄耀南，钟静，黄日明，钟金淑子；一种多糖的新用途。申请号: CN202510042159.8
2008年–2012年：英国谢菲尔德大学博士奖学金
2006年–2007年：澳门高等教育局研究生奖学金
2002年–2006年：澳门教育暨青年局大专奖学金
2002年：澳门莲花奖
1999年：澳门总督奖
2025年2月至今：澳门特区政府生命科学道德委员会成员
2023年7月–2025年6月：澳门特区政府人才发展委员会大健康产业专责小组成员
2025年3月至今：澳门科技大学医学伦理委员会成员
2024年8月至今：澳门科技大学临床伦理委员会成员
2019年8月至今：澳门科技大学学术诚信委员会成员
2019年8月至今：澳门科技大学学生纪律奖惩委员会委员
2019年7月–2020年8月：澳门科技大学医药综合教学实验管理委员会委员
