• 全部
  • 關於學院
  • 教研團隊
  • 學院新聞
  • 學院課程
  • 醫療培訓中心
  • 藥學院
  • 科大醫院
  • 研究
  • 教學設施
  • 學生資訊
  • 聯繫我們
简体 EN
韓守裕
副教授
所在部門： 醫學院(FMD)
聯係電話： 853 8897 3319
辦公室： 擎天匯校區 PP-R209a
電子信箱： dbaptistahon@must.edu.mo
我在愛丁堡大學獲得了生理學博士學位，研究方向為鐵超載性心肌病變的分子決定因素。目前，我是澳門科技大學醫學院的副教授兼助理院長，同時擔任澳門人工智慧醫學研究院的助理主任，並在英國鄧迪大學擔任榮譽講師。

我的實驗室研究膜受體（離子通道和G蛋白偶聯受體）在健康與疾病中的作用。我們結合膜片鉗電生理方法與分子、生化和遺傳技術，研究以下幾個主要領域：分子藥理學、癌症生物學、神經科學和傳染病。

我還負責本科生和研究生的生理學、神經科學和微生物學教學。我曾共同撰寫多篇發表在《自然醫學》和《美國國家科學院院刊》等著名期刊的論文。此外，我還擔任多家知名期刊的編輯和審稿人，為科學界做出貢獻。
學歷

博士 生理學（2012）英國愛丁堡大學
碩士 藥理學（2004）英國曼徹斯特大學
學士 生物醫學科學（2003）英國曼徹斯特大學

教學領域

生理學、藥理學、微生物學、神經科學、溝通技巧

研究領域

癌症、圍手術期醫學、傳染病、離子通道結構功能與藥理學、G蛋白偶聯受體（GPCR）結構功能與藥理學

工作經歷

  • 2024年至今 副教授（澳門科技大學醫學院）

  • 2023年至今 助理院長（澳門科技大學醫學院）

  • 2023年至今 助理所長（澳門科技大學醫學院人工智能醫學研究所）

  • 2020-2024 助理教授（澳門科技大學醫學院）

  • 2019-2020 Stewart Trust 研究員（英國鄧迪大學醫學院）

  • 2010-2019 博士後研究員（英國鄧迪大學醫學院）

學術出版物（精選）

  1. Lok L.S.C., Monteiro O. and Baptista-Hon      D.T. Unlocking Longevity: How Blocking IL-11 Signalling Could      Extend Healthspan and Lifespan. Medcomm – Future Medicine (2024;      Accepted, in press) (Corresponding author).

  2. Wong I.N., Monteiro O., Baptista-Hon D.,      Wang K., Lu W.Y., Sun Z., Nei S. and Yin Y. Leveraging foundation and      large language models in medical artificial intelligence. Chinese      Medical Journal (2024; Accepted, in press) (IF: 7.5).

  3. Singleton      S., Dieterle C., Walker D.J., Runeberg T., Oswald A.S., Rosenqvist G.,      Robertson L., McCarthy T., Sarkar S., Baptista-Hon D. and      Hales T.G. Activation of µ receptors by SR-17018 through a distinctive      mechanism. Neuropharmacology (2024) 258:110093 (IF: 4.7).

  4. Zhang K., Zhou H. Y., Baptista-Hon      D.T., Gao Y., Liu X., Oermann E., Xu S., Jin S., Zhang J., Sun Z.,      Yin Y., Razmi R. M., Loupy A., Beck S., Qu J., Wu J., and International      Consortium of Digital Twins in Medicine. Concepts and Applications of      Digital Twins in Healthcare and Medicine. Patterns (2024)      5(8):101028 (IF: 6.7; Co-first author).

  5. Ye Y., Tong H.Y.K., Chong W.H., Li      Z., Tam P.K.H., Baptista-Hon,      D.T. and Monteiro O. A systematic review and meta-analysis of the      effects of long-term antibiotic use on cognitive outcomes. Scientific Reports (2024) 14:4026.      (IF: 4.6; Co-corresponding author)

  6. Wang, J., Gao, Y., Wang, F., Zeng,      S., Li, J., Miao, H., Wang, T., Baptista-Hon,      D., Monteiro, O., Cheng, L., Lu, Y., Luo, Z., Zhu, J., Zhou, Y.      and Zhang, K. Accurate Estimation of Biological Age Using a      Transformer-based Holistic Representation of Multi-modal Image      Information. Proceedings of the      National Academy of Sciences (2024) 121(3): e2308812120. (IF: 12.78)

  7. Sarkar S. and Baptista-Hon D.T.      Application of machine learning to classify cancers of unknown primary. Medcomm      – Oncology (2023) 2:e63 (Corresponding author).

  8. Wei J., Baptista-Hon D.T.,      Wang Z., Li G., Herrler T., Dai C., Liu K., Yu B., Chen X., Yang M., Han      D., Gao Y., Huang R.-L., Guo L., Zhang K. and Li Q. Bioengineered human      tissue regeneration and repair using endogenous stem cells. Cell      Reports Medicine (2023) 4(8):101156 (IF: 16.99, Co-first author).

  9. Wang G., Liu X., Wang K., Gao Y., Li      G., Baptista-Hon D.T., Yang X.H., Xue K., Tai W.H., Jiang      Z., Cheng L., Fok M., Lau J. Y.-N., Yang S., Lu L., Zhang P. and Zhang K. Deep-learning-enabled      protein–protein interaction analysis for prediction of SARS-CoV-2      infectivity and variant evolution. Nature Medicine (2023) 29:2007-2018      (IF: 87.24, Co-first author).

  10. Gao Y., Baptista-Hon D.T. and Zhang K. The inevitable      transformation of medicine and research by large language models: The possibilities      and pitfalls. Medcomm – Future      Medicine (2023) 2(2):e49.

  11. Kuo C.W.S., Dobi S., Gök C., Costa      A., Main A., Robertson-Gray O., Baptista-Hon      D.T., Wypijewski K.J., Costello H., Hales T.G., MacQuaide N.,      Smith G.L. and Fuller W. Palmitoylation of the pore-forming subunit of      Ca(v)1.2 controls channel voltage sensitivity and calcium transients in      cardiac myocytes. Proceedings of the      National Academy of Sciences (2023) 120(7): e2207887120.      (IF: 12.78)

  12. Baptista-Hon D.T., Fesalbon G.J.W. and Monteiro O. Changing      clinical features of the 2022 monkeypox global health emergency. Medcomm – Future Medicine (2022) 1(2):e24      (First and corresponding author)

  13. Lao U.S., Law C.F., Baptista-Hon D.T. and      Tomlinson B. Systematic review and meta-analysis of statin use and      mortality, intensive care unit admission and requirement for mechanical      ventilation in COVID-19 patients. J      Clin Med (2022) 11(18):5454 (IF: 4.96, Co-corresponding author)

  14. Monteiro O., Li Y.W. and Baptista-Hon D.T.      Phylogenomic characterisation of the 2022 outbreak of monkeypox virus –      The importance of sustained genetic surveillance. Medcomm – Future Medicine (2022) 1:e16. (Corresponding author)

  15. Li G., Zhou Z., Du P., Zhan M., Li      N., Xiong X., Tang S., Man M., Baptista-Hon      D.T. and Lu L. Heterologous mRNA vaccine booster increases      neutralization of SARS-CoV-2 Omicron BA.2 variant. Signal Transduct Target Ther (2022) 7(1):243. (IF: 38.15, Co-corresponding author)

  16. Zhou Z.C., Du P., Li N., Xiong X.X.,      Tang S.J., Dai Q.J., Wang T.R., Yu M.X., Man M., Lam K., Baptista-Hon D.T., Monteiro      O., Ng W.S., Lee U.M., Liu Z.H., Zhang K. and Li G. Homologous or      heterogenous vaccination boosters enhance neutralizing activities against      SARS-CoV-2 Omicron BA.1 variant. MedComm      (2022) 3(2):e143.

  17. Ao D., Lan T., He X., Liu J., Chen      L., Baptista-Hon D.T.,      Zhang K. and Wei X. SARS-CoV-2 Omicron variant: Immune escape and vaccine      development. MedComm (2022) 3(1):e126.

  18. Monteiro O., Bhaskar A., Ng K.M.,      Murdoch C.E. and Baptista-Hon      D.T. Computer based virtual laboratory simulations: LabHEART      cardiac physiology practical. Adv      Physiol Ed (2021) 45(4):856-868. (IF: 2.89, Corresponding author)

  19. Monteiro O., Bhaskar A., Wong I.N.,      Ng K.M. and Baptista-Hon D.T.      Teaching bioelectricity and neurophysiology to medical students using      LabAXON simulations. Adv Physiol Ed      (2021) 45(4):702-708. (IF: 2.89, Corresponding      author)

  20. Li G., Zhou Z.C., Du P., Yu M.X., Li      N., Xiong X.X., Huang H., Liu Z.H., Dai Q.J., Zhu J., Guo C.B., Wu S.Y., Baptista-Hon D.T., Miao M.,      Ming L.W., Wu Y., Zeng F.X., Zhang C.L., Zhang E.D., Song H.F., Liu J.H.,      Lau J.Y.N., Xiang A.P. and Zhang K. The SARS-CoV-2 spike L452R-E484Q      co-variant in the Indian B.1.617 strain Showed Significant Reduction in      the Neutralization Activity of Immune Sera. Precision Clinical Medicine (2021) pbab016. https://doi.org/10.1093/pcmedi/pbab016

  21. Zhou Z.C., Du P., Yu M.X., Baptista-Hon D.T., Miao M.,      Xiang A.P., Lau J.Y.N., COVID-19 Immunity Investigation Group, Li G. and      Zhang K. Assessment of Infectivity and the Impact on Neutralizing Activity      of Immune Sera of the COVID-19 Variant, CAL.20C. Signal Transduct Target Ther (2021) 6(1):285. https://doi.org/10.1038/s41392-021-00695-0      (IF: 21.2).

  22. Singleton S., Baptista-Hon D.T., Edelsten E., McCaughey K.S.,      Camplisson E. and Hales T.G. TRV130 partial agonism and capacity to induce      anti-nociceptive tolerance revealed through reducing available μ-opioid      receptor number. Br J Pharmacol      (2021) 178(8):1855-1868. https://doi.org/10.1111/bph.15409 (IF: 6.81).

  23. Baptista-Hon D.T., Smith M., Singleton S., Antonides L.H.,      Nic Daeid N., McKenzie C. and Hales T.G. Activation of μ-opioid receptors      by MT-45 (1-cyclohexyl-4-(1,2-diphenylethyl)piperazine) and its      fluorinated derivatives. Br J Pharmacol (2020) 177(15):3436-3448. https://doi.org/10.1111/bph.15064      (IF: 6.81).

  24. 24.   Gottschald Chiodi C., Baptista-Hon D.T., Hunter W.N. and Hales T.G. Amino acid substitutions in the human homomeric β3 GABAA receptor that enable activation by GABA. J Biol Chem (2019) 294(7):2375-2385 (IF: 4.28).

  25. Baptista-Hon D.T.*, Elajnaf T.* (joint first authorship) and Hales T.G. Potent      inactivation-dependent inhibition of adult and neonatal NaV1.5      channels by lidocaine and levobupivacaine. Anaesth Analg (2018) 127(3):650-660 (IF: 3.83).

  26. Wright L., Baptista-Hon      D.T., Bull F., Dalgaty F., Gallacher M., Woods J.A., Ibbotson S.H.      and Hales T.G. Phototoxicity      causes pain by activating TRPV1 receptors. Pain (2018) 159(2):284-297 (IF: 6.03).

  27. Bull F., Baptista-Hon      D.T., Lambert J.J., Walwyn W. and Hales T.G. Morphine activation      of mu opioid receptors causes disinhibition of neurons in the ventral      tegmental area mediated by β-arrestin 2 and c-src. Scientific Reports (2017) 7(1):9969 (IF: 4.53).

  28. Bull F., Baptista-Hon      D.T., Sneddon C., Wright L., Walwyn W. and Hales T.G. Src kinase      inhibition attenuates morphine tolerance without affecting reinforcement      or psychomotor stimulation. Anaesthesiology      (2017) 127(5):878-889 (IF: 4.14).

  29. Baptista-Hon D.T.,      Gulbinaite S. and Hales T.G. The identity of a loop G residue in the GABAA      receptor α1 subunit influences gating efficacy. J Physiol. (2017) 595(5):1725-1741 (IF: 4.95).

  30. Baptista-Hon D.T., Krah A.,      Zachariae U. and Hales T.G. A role for loop G in the β1 strand in GABAA      receptor activation. J Physiol.      (2016) 594(19):5555-71 (IF: 4.95).

  31. 31.   House C.D., Wang B.D., Ceniccola K., Williams R., Simaan M., Olender J., Patel V., Baptista-Hon D.T., Annunziata C.M., Gutkind J.S., Hales T.G. and Lee N.H. Voltage-gated Na+ Channel Activity Increases Colon Cancer Transcriptional Activity and Invasion Via Persistent MAPK Signaling. Sci Rep. (2015) 5:11541 (IF: 4.53).

  32. Morton R.A., Baptista-Hon D.T., Hales T.G. and Lovinger D.M. Agonist- and antagonist-induced      up-regulation of surface 5-HT3 A receptors. Br J Pharmacol. (2015) 172:4066-77 (IF: 6.81).

  33. Baptista‐Hon D.T., Robertson F.M., Robertson G.B.,      Owen S.J., Rogers G.W., Lydon E.L., Lee N.H. and Hales T.G. Potent      inhibition by ropivacaine of metastatic colon cancer SW620 cell invasion      and NaV1.5 channel function. Br J Anaesth. (2014) 113 S: i39-i48 (IF: 6.50).

  34. Baptista-Hon D.T., Deeb T.Z., Lambert J.J., Peters J.A. and Hales      T.G. The minimum M3-M4 loop length of neurotransmitter-activated      pentameric receptors is critical for the structural integrity of      cytoplasmic portals. J Biol Chem.      (2013) 288: 21558-68 (IF: 4.28).

  35. Othman N.A, Gallacher, M., Deeb T.Z.,      Baptista-Hon, D.T.,      Perry, D.C. and Hales T.G. Influences on blockade by TBPS of GABAA      receptor spontaneous gating, agonist activation and desensitization. J Physiol. (2012) 590:163-78 (IF: 4.95).

  36. Baptista-Hon D.T., Othman N.A., Sharp D., Deeb T.Z., and Hales T.G. The 5-HT3B subunit affects high potency 5-HT3 receptor inhibition by morphine. Br J Pharmacol. (2012) 165:693-704 (IF: 6.81).


書籍

1.       Local Anaesthesia and Cancer, Hales T.G. & Baptista-Hon D.T. (2023): In Perioperative Care of the Cancer Patient. Editors: Hagberg, Gottumukkala, Riedel, Nates & Buggy. Elsevier.

2.       Monograph (2020): A Dream Come True. Chief editors: Patil N.G., Baptista-Hon D.T., Lam C.W.K. Faculty of Medicine, Macau University of Science and Technology, Macau SAR, China.


專利
專業認證和獎項
專業協會會員資格