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繁體 EN
韩守裕
助理院长及副教授(微生物学)
所在部门： 医学院(FMD)
联系电话： 853 8897 3319
办公室： 擎天汇校区 PP-R209a
电子信箱： dbaptistahon@must.edu.mo
我在爱丁堡大学获得了生理学博士学位，研究方向为铁超载性心肌病变的分子决定因素。目前，我是澳门科技大学医学院的副教授兼助理院长，同时担任澳门人工智慧医学研究院的助理主任，并在英国邓迪大学担任荣誉讲师。

我的实验室研究膜受体（离子通道和G蛋白偶联受体）在健康与疾病中的作用。我们结合膜片钳电生理方法与分子、生化和遗传技术，研究以下几个主要领域：分子药理学、癌症生物学、神经科学和传染病。
学历

  • 博士 生理学（2012）英国爱丁堡大学

  • 硕士 药理学（2004）英国曼彻斯特大学

  • 学士 生物医学科学（2003）英国曼彻斯特大学

教学领域

生理学、药理学、微生物学、神经科学、沟通技巧

研究领域

癌症、围手术期医学、传染病、离子通道结构功能与药理学、G蛋白偶联受体（GPCR）结构功能与药理学

工作经历

  • 2024年至今 副教授（澳门科技大学医学院）

  • 2023年至今 助理院长（澳门科技大学医学院）

  • 2023年至今 助理所长（澳门科技大学医学院人工智能医学研究所）

  • 2020-2024 助理教授（澳门科技大学医学院）

  • 2019-2020 Stewart Trust 研究员（英国邓迪大学医学院）

  • 2010-2019 博士后研究员（英国邓迪大学医学院）


学术出版物（精选）

  1. Wang J., Wang K., Yu Y., Lu Y., Xiao W., Sun Z., Liu F., Zou Z., Gao Y., Yang L., Zhou H-Y., Miao H., Zhao W., Huang L., Zeng L., Guo R., Chong I., Deng B., Cheng L., Chen X., Luo J., Zhu M-H., Baptista-Hon D., Monteiro O., Li M., Ke Y., Li J., Zeng S., Guan T., Zeng J., Xue K., Oermann E., Luo H., Yin Y., Zhang K., Qu J. Self-improving generative foundation model for synthetic medical image generation and clinical applications. Nature Medicine (2024; https://doi.org/10.1038/s41591-024-03359-y) (IF: 58.7).

  2. Lok L.S.C., Sarkar S., Lam C.C.I., Law C.F., Chau S.T., Leung C.Y.T., Cheang W.H., Li T., Monteiro O. and Baptista-Hon D.T. Long COVID across SARS-CoV-2 variants: Clinical features, pathogenesis, and future directions. Medcomm – Future Medicine (2024; Accepted, in press) (Corresponding author)

  3. Lok L.S.C., Monteiro O. and Baptista-Hon D.T. Unlocking Longevity: How Blocking IL-11 Signalling Could Extend Healthspan and Lifespan. Medcomm – Future Medicine (2024) 3(4):e101 (Corresponding author).

  4. Wong I.N., Monteiro O., Baptista-Hon D., Wang K., Lu W.Y., Sun Z., Nei S. and Yin Y. Leveraging foundation and large language models in medical artificial intelligence. Chinese Medical Journal (2024) 137(21) (IF: 7.5).

  5. Singleton S., Dieterle C., Walker D.J., Runeberg T., Oswald A.S., Rosenqvist G., Robertson L., McCarthy T., Sarkar S., Baptista-Hon D. and Hales T.G. Activation of µ receptors by SR-17018 through a distinctive mechanism. Neuropharmacology (2024) 258:110093 (IF: 4.7).

  6. Zhang K., Zhou H. Y., Baptista-Hon D.T., Gao Y., Liu X., Oermann E., Xu S., Jin S., Zhang J., Sun Z., Yin Y., Razmi R. M., Loupy A., Beck S., Qu J., Wu J., and International Consortium of Digital Twins in Medicine. Concepts and Applications of Digital Twins in Healthcare and Medicine. Patterns (2024) 5(8):101028 (IF: 6.7; Co-first author).

  7. Ye Y., Tong H.Y.K., Chong W.H., Li Z., Tam P.K.H., Baptista-Hon, D.T. and Monteiro O. A systematic review and meta-analysis of the effects of long-term antibiotic use on cognitive outcomes. Scientific Reports (2024) 14:4026. (IF: 4.6; Co-corresponding author)

  8. Wang, J., Gao, Y., Wang, F., Zeng, S., Li, J., Miao, H., Wang, T., Baptista-Hon, D., Monteiro, O., Cheng, L., Lu, Y., Luo, Z., Zhu, J., Zhou, Y. and Zhang, K. Accurate Estimation of Biological Age Using a Transformer-based Holistic Representation of Multi-modal Image Information. Proceedings of the National Academy of Sciences (2024) 121(3): e2308812120. (IF: 12.78)

  9. Sarkar S. and Baptista-Hon D.T. Application of machine learning to classify cancers of unknown primary. Medcomm – Oncology (2023) 2:e63 (Corresponding author).

  10. Wei J., Baptista-Hon D.T., Wang Z., Li G., Herrler T., Dai C., Liu K., Yu B., Chen X., Yang M., Han D., Gao Y., Huang R.-L., Guo L., Zhang K. and Li Q. Bioengineered human tissue regeneration and repair using endogenous stem cells. Cell Reports Medicine (2023) 4(8):101156 (IF: 16.99, Co-first author).

  11. Wang G., Liu X., Wang K., Gao Y., Li G., Baptista-Hon D.T., Yang X.H., Xue K., Tai W.H., Jiang Z., Cheng L., Fok M., Lau J. Y.-N., Yang S., Lu L., Zhang P. and Zhang K. Deep-learning-enabled protein–protein interaction analysis for prediction of SARS-CoV-2 infectivity and variant evolution. Nature Medicine (2023) 29:2007-2018 (IF: 87.24, Co-first author).

  12. Gao Y., Baptista-Hon D.T. and Zhang K. The inevitable transformation of medicine and research by large language models: The possibilities and pitfalls. Medcomm – Future Medicine (2023) 2(2):e49.

  13. Kuo C.W.S., Dobi S., Gök C., Costa A., Main A., Robertson-Gray O., Baptista-Hon D.T., Wypijewski K.J., Costello H., Hales T.G., MacQuaide N., Smith G.L. and Fuller W. Palmitoylation of the pore-forming subunit of Ca(v)1.2 controls channel voltage sensitivity and calcium transients in cardiac myocytes. Proceedings of the National Academy of Sciences (2023) 120(7): e2207887120. (IF: 12.78)

  14. Baptista-Hon D.T., Fesalbon G.J.W. and Monteiro O. Changing clinical features of the 2022 monkeypox global health emergency. Medcomm – Future Medicine (2022) 1(2):e24 (First and corresponding author)

  15. Lao U.S., Law C.F., Baptista-Hon D.T. and Tomlinson B. Systematic review and meta-analysis of statin use and mortality, intensive care unit admission and requirement for mechanical ventilation in COVID-19 patients. J Clin Med (2022) 11(18):5454 (IF: 4.96, Co-corresponding author)

  16. Monteiro O., Li Y.W. and Baptista-Hon D.T. Phylogenomic characterisation of the 2022 outbreak of monkeypox virus – The importance of sustained genetic surveillance. Medcomm – Future Medicine (2022) 1:e16. (Corresponding author)

  17. Li G., Zhou Z., Du P., Zhan M., Li N., Xiong X., Tang S., Man M., Baptista-Hon D.T. and Lu L. Heterologous mRNA vaccine booster increases neutralization of SARS-CoV-2 Omicron BA.2 variant. Signal Transduct Target Ther (2022) 7(1):243. (IF: 38.15, Co-corresponding author)

  18. Zhou Z.C., Du P., Li N., Xiong X.X., Tang S.J., Dai Q.J., Wang T.R., Yu M.X., Man M., Lam K., Baptista-Hon D.T., Monteiro O., Ng W.S., Lee U.M., Liu Z.H., Zhang K. and Li G. Homologous or heterogenous vaccination boosters enhance neutralizing activities against SARS-CoV-2 Omicron BA.1 variant. MedComm (2022) 3(2):e143.

  19. Ao D., Lan T., He X., Liu J., Chen L., Baptista-Hon D.T., Zhang K. and Wei X. SARS-CoV-2 Omicron variant: Immune escape and vaccine development. MedComm (2022) 3(1):e126.

  20. Monteiro O., Bhaskar A., Ng K.M., Murdoch C.E. and Baptista-Hon D.T. Computer based virtual laboratory simulations: LabHEART cardiac physiology practical. Adv Physiol Ed (2021) 45(4):856-868. (IF: 2.89, Corresponding author)

  21. Monteiro O., Bhaskar A., Wong I.N., Ng K.M. and Baptista-Hon D.T. Teaching bioelectricity and neurophysiology to medical students using LabAXON simulations. Adv Physiol Ed (2021) 45(4):702-708. (IF: 2.89, Corresponding author)

  22. Li G., Zhou Z.C., Du P., Yu M.X., Li N., Xiong X.X., Huang H., Liu Z.H., Dai Q.J., Zhu J., Guo C.B., Wu S.Y., Baptista-Hon D.T., Miao M., Ming L.W., Wu Y., Zeng F.X., Zhang C.L., Zhang E.D., Song H.F., Liu J.H., Lau J.Y.N., Xiang A.P. and Zhang K. The SARS-CoV-2 spike L452R-E484Q co-variant in the Indian B.1.617 strain Showed Significant Reduction in the Neutralization Activity of Immune Sera. Precision Clinical Medicine (2021) pbab016. https://doi.org/10.1093/pcmedi/pbab016

  23. Zhou Z.C., Du P., Yu M.X., Baptista-Hon D.T., Miao M., Xiang A.P., Lau J.Y.N., COVID-19 Immunity Investigation Group, Li G. and Zhang K. Assessment of Infectivity and the Impact on Neutralizing Activity of Immune Sera of the COVID-19 Variant, CAL.20C. Signal Transduct Target Ther (2021) 6(1):285. https://doi.org/10.1038/s41392-021-00695-0 (IF: 21.2).

  24. Singleton S., Baptista-Hon D.T., Edelsten E., McCaughey K.S., Camplisson E. and Hales T.G. TRV130 partial agonism and capacity to induce anti-nociceptive tolerance revealed through reducing available μ-opioid receptor number. Br J Pharmacol (2021) 178(8):1855-1868. https://doi.org/10.1111/bph.15409 (IF: 6.81).

  25. Baptista-Hon D.T., Smith M., Singleton S., Antonides L.H., Nic Daeid N., McKenzie C. and Hales T.G. Activation of μ-opioid receptors by MT-45 (1-cyclohexyl-4-(1,2-diphenylethyl)piperazine) and its fluorinated derivatives. Br J Pharmacol (2020) 177(15):3436-3448. https://doi.org/10.1111/bph.15064 (IF: 6.81).

  26. Gottschald Chiodi C., Baptista-Hon D.T., Hunter W.N. and Hales T.G. Amino acid substitutions in the human homomeric β3 GABAA receptor that enable activation by GABA. J Biol Chem (2019) 294(7):2375-2385 (IF: 4.28).

  27. Baptista-Hon D.T.*, Elajnaf T.* (joint first authorship) and Hales T.G. Potent inactivation-dependent inhibition of adult and neonatal NaV1.5 channels by lidocaine and levobupivacaine. Anaesth Analg (2018) 127(3):650-660 (IF: 3.83).

  28. Wright L., Baptista-Hon D.T., Bull F., Dalgaty F., Gallacher M., Woods J.A., Ibbotson S.H. and Hales T.G. Phototoxicity causes pain by activating TRPV1 receptors. Pain (2018) 159(2):284-297 (IF: 6.03).

  29. Bull F., Baptista-Hon D.T., Lambert J.J., Walwyn W. and Hales T.G. Morphine activation of mu opioid receptors causes disinhibition of neurons in the ventral tegmental area mediated by β-arrestin 2 and c-src. Scientific Reports (2017) 7(1):9969 (IF: 4.53).

  30. Bull F., Baptista-Hon D.T., Sneddon C., Wright L., Walwyn W. and Hales T.G. Src kinase inhibition attenuates morphine tolerance without affecting reinforcement or psychomotor stimulation. Anaesthesiology (2017) 127(5):878-889 (IF: 4.14).

  31. Baptista-Hon D.T., Gulbinaite S. and Hales T.G. The identity of a loop G residue in the GABAA receptor α1 subunit influences gating efficacy. J Physiol. (2017) 595(5):1725-1741 (IF: 4.95).

  32. Baptista-Hon D.T., Krah A., Zachariae U. and Hales T.G. A role for loop G in the β1 strand in GABAA receptor activation. J Physiol. (2016) 594(19):5555-71 (IF: 4.95).

  33. House C.D., Wang B.D., Ceniccola K., Williams R., Simaan M., Olender J., Patel V., Baptista-Hon D.T., Annunziata C.M., Gutkind J.S., Hales T.G. and Lee N.H. Voltage-gated Na+ Channel Activity Increases Colon Cancer Transcriptional Activity and Invasion Via Persistent MAPK Signaling. Sci Rep. (2015) 5:11541 (IF: 4.53).

  34. Morton R.A., Baptista-Hon D.T., Hales T.G. and Lovinger D.M. Agonist- and antagonist-induced up-regulation of surface 5-HT3 A receptors. Br J Pharmacol. (2015) 172:4066-77 (IF: 6.81).

  35. Baptista‐Hon D.T., Robertson F.M., Robertson G.B., Owen S.J., Rogers G.W., Lydon E.L., Lee N.H. and Hales T.G. Potent inhibition by ropivacaine of metastatic colon cancer SW620 cell invasion and NaV1.5 channel function. Br J Anaesth. (2014) 113 S: i39-i48 (IF: 6.50).

  36. Baptista-Hon D.T., Deeb T.Z., Lambert J.J., Peters J.A. and Hales T.G. The minimum M3-M4 loop length of neurotransmitter-activated pentameric receptors is critical for the structural integrity of cytoplasmic portals. J Biol Chem. (2013) 288: 21558-68 (IF: 4.28).

  37. Othman N.A, Gallacher, M., Deeb T.Z., Baptista-Hon, D.T., Perry, D.C. and Hales T.G. Influences on blockade by TBPS of GABAA receptor spontaneous gating, agonist activation and desensitization. J Physiol. (2012) 590:163-78 (IF: 4.95).

  38. Baptista-Hon D.T., Othman N.A., Sharp D., Deeb T.Z., and Hales T.G. The 5-HT3B subunit affects high potency 5-HT3 receptor inhibition by morphine. Br J Pharmacol. (2012) 165:693-704 (IF: 6.81).

Peer-reviewed conference proceedings

  1. Singh K., Baptista-Hon D.T., Hewitt M., Kouli O., Hossain-Ibrahim K. and Hales T.G. Determining an in vitro dose-response relationship of photodynamic therapy with first and second-generation photosensitisers for high grade tumours. 17th International Photodynamic Association World Congress (2019). DOI: 10.1117/12.2527574.

  2. Smith M., Baptista-Hon D.T., Antonides L., Mckenzie C., Daeid N. and Hales T.G. Activation of the mu-opioid receptor by MT-45 and its synthetic and metabolic derivatives. Br J Anaesth (2019). DOI: 10.1016/j.bja.2018.10.047 (IF: 6.50).

  3. Singleton S., Baptista-Hon D.T., Bull F. and Hales T.G. Measuring the bias of morphine, oxycodone, and buprenorphine for G protein activation vs β-arrestin2 recruitment to the μ opioid receptor. Br J Anaesth (2019). DOI: 10.1016/j.bja.2018.10.038 (IF: 6.50).

  4. Pospiech G., Baptista-Hon D.T. and Hales T.G. Consequences of dynamic changes in palmitoylation of NaV1.5 voltage-gated Na+ channels. Br J Anaesth (2018) 120(5): E8 (IF: 6.50).

  5. Ong S., Elajnaf T., Baptista-Hon D.T. and Hales T.G. Voltage-activated Na+ channels as novel targets for treating metastatic colon cancer: investigating the effect of local anaesthetics on NaV1.5 channels in metastatic colon cancer. Br J Anaesth (2016) 116(6):E935 (IF: 6.50).

  6. Vickery O.N., Baptista-Hon D.T., Seeliger D., Hales T.G. and Zachariae U. Investigating the effect of sodium and voltage on δ-opioid receptors. Biophysical J (2015); 108(2): 414 (IF: 3.67).

  7. Millar F.R., Baptista-Hon D.T., O’Neill S.C. and Díaz M.E. Increasing anti-oxidant capacity reverses iron overload mediated dysfunction in cardiomyocytes. Heart (2011) 97:A96-A97 (IF:5.21)

  8. Baptista‐Hon D.T., Elliott A.C. and Díaz M.E. Iron(II) modulation of cardiac ryanodine receptors (RyR2). Biophysical J (2009); 96(3): 113‐114 (IF: 3.67).

  9. Baptista‐Hon D.T., Díaz M.E. and Elliott A.C. Acute exposure to iron (II) alters calcium handling in isolated rat ventricular myocytes. J Mol Cell Cardiol (2005); 39: 179 (IF: 5.01).


书籍

1.        Local Anaesthesia and Cancer, Hales T.G. & Baptista-Hon D.T. (2023): In Perioperative Care of the Cancer Patient. Editors: Hagberg, Gottumukkala, Riedel, Nates & Buggy. Elsevier. 2.        Monograph (2020): A Dream Come True. Chief editors: Patil N.G., Baptista-Hon D.T., Lam C.W.K. Faculty of Medicine, Macau University of Science and Technology, Macau SAR, China.


专利
专业认证和奖项
专业协会会员资格