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DE SOUZA MONTEIRO, OLIVIA
Assistant Professor of Pharmacology
Department: Faculty of Medicine
Office: Room PP-R209b, Est. Seak Pai Van Praia Park , Rés-Do-Chão R, Coloane, Macau
E-mail: omonteiro@must.edu.mo
Dr. Olivia Monteiro completed her undergraduate degree in Biomedical Sciences at the University of Aberdeen, UK before earning her PhD from the University of Edinburgh, UK in 2010. With a primary focus on neuropharmacology and cognitive neuroscience, her laboratory investigates the impacts of early life adversities and neurodegenerative diseases on cognitive function. Her research focuses on the pharmacological manipulations of GABAARs to impair or to enhance cognition. Additionally, her laboratory explores the emerging phenomenon of long COVID, examining alterations in immune mediators and neurotransmitter levels within the local population. Through her interdisciplinary approach, Dr. Olivia Monteiro aims to contribute to the advancement of both basic and clinical neuroscience, with the ultimate goal of improving cognitive health in individuals affected by cognitive impairments.
Dr. Olivia Monteiro teaches Pharmacology and Physiology to Year 1 and Year 2 MBBS students, as well as the longitudinal Language and Communication module. She also conducts classes aimed at enhancing English language proficiency for Year 1 MBBS students. In her interdisciplinary teaching role, Dr. Monteiro delivers lectures on AI in Medicine for General Education courses, Biology for students in the Faculty of Innovation Engineering, and Pharmacology and Therapeutics for both the Doctorate in Biomedical Sciences and Master of Nursing programmes.
Academic Qualification

2010:  PhD, University of Edinburgh; Mechanisms of Dendritic Peptide Release. 

            BBSRC funded studentship

2004:   BSc. Hons, University of Aberdeen; Biomedical Sciences (Pharmacology)


Teaching Area

Pharmacology, Physiology, Neuroscience, Language and Communication

Course

Title

MBBS   Year 1

Language and 

Communications

MBBS   Year 1

Foundation Block

MBBS   Year 1

Respiratory Block

MBBS   Year 1

Cardiovascular Block

MBBS   Year 1

Gastrointestinal Block

MBBS   Year 2

Language and 

Communications

MBBS   Year 2

Haematology and 

Immunology Block

MBBS   Year 2

Endocrine Block

MBBS   Year 2

Urogenital Block

MBBS   Year 2

Musculoskeletal Block

MBBS   Year 2

Nervous System Block

MBBS   Year 2

Special Senses Block

FIE   Year 1

Biology

General Education

AI in medicine

DPBS

PhD in Biomedical 

Sciences

MHNZ

Master of Nursing

PhD student supervision

Master student supervision


Research Area

Neuropharmacology, cognitive neuroscience, behavioural neuroscience, early life adversity, post-operative cognitive deficits caused by general anaesthesia, long COVID

Working Experience

2020 – present: Assistant professor 2012 – 2019: Postdoctoral Research Scientist, School of Medicine, University of Dundee 2009 – 2011: Postdoctoral Research Scientist, School of Life Science, University of Dundee.

Academic Publication (selected)

1.       Patil NG, Kou NL, Baptista-Hon DT, Monteiro O (In press 2025) Artificial Intelligence in Medical Education: A Practical Guide for Educators MedComm – Future Medicine Corresponding Author

2.       Wang Jinzhuo Wang, J., Wang, K., Yu, Y…Monteiro O…Zhang K, Qu J. (December 2024) Self-improving generative foundation model for synthetic medical image generation and clinical applications. Nature Medicine. IF 58.7. Contributing Author

3.       Lok L.S.C.*, Sarkar S.*, Law C.F., Chau S.T., Leung C.Y., Cheang W.H., Li T., Monteiro O.#, Baptista-Hon D.T. # (In press 2024) Long COVID Across SARS-CoV-2 Variants: Clinical Features, Pathogenesis and Future Directions MedComm – Future Medicine Corresponding Author

4.       Wong IN*, Monteiro O*, Baptista-Hon D, Wang K, Lu Wy, Sun Z, Nei S, Yin Y (November 2024). Leveraging foundation and large language models in medical artificial intelligence Chinese Medical Journal. IF 7.5. 1st Author

5.       L. S. C. Lok, O. Monteiro, D. T. Baptista-Hon (October 2024) Unlocking longevity: How blocking IL-11 signaling could extend healthspan and lifespan. MedComm – Future Medicine

6.       Zhang S, Yang B, Yang H, Zhao J, Zhang Y, Gao Y, Monteiro O, Zhang K, Liu B, Wang S (June 2024). Potential rapid intraoperative cancer diagnosis using dynamic full-field optical coherence tomography and deep learning: A prospective cohort study in breast cancer patients. Science Bulletin. IF 18.9. Contributing Author

7.       Sarkar S and Monteiro O (April 2024) Understanding long COVID—The role of serotonin in cognitive impairment MedComm – Future Medicine Corresponding Author 

8.       Guan T, Monteiro O, Chen D, Luo Z, Chi K, Li Z, Liang Y, Lu Z, Jiang Y, Yang J, Lin W, Yi M, Zhang K, Ou C (26/03/2024). Long-term and short-term cardiovascular disease mortality among patients of 21 non-metastatic cancers. Journal of Advanced Research. IF 10.7. 2nd Author

9.       Ye Y, Tong HYK, Chong WH, Li Z, Tam PKH, Baptista-Hon DT, Monteiro O (18/02/2024). A systematic review and meta-analysis of the effects of long-term antibiotic use on cognitive outcomes. Scientific Reports. IF 5.5. Corresponding Author

10.   Zhou X, He Y, Xu T, Wu Z, Guo W, Xu X, Liu Y, Zhang Y, Shang H, Huang L, Yao Z, Li Z, Su L, Li Z, Feng T, Zhang S, Monteiro O, Cunha RA, Huang ZL, Zhang K, Li Y, Cai X, Qu J, Chen JF (08/02/2024). 40 Hz light flickering promotes sleep through cortical adenosine signaling. Cell Research. IF 44.1. Contributing Author

11.   Wang J, Gao Y, Wang F, Zeng S, Li J, Miao H, Wang T, Zeng J, Baptista-Hon D, Monteiro O, Guan T, Cheng L, Lu Y, Luo Z, Li M, Zhu JK, Nie S, Zhang K, Zhou Y (08/01/2024). Accurate estimation of biological age and its application in disease prediction using a multimodal image Transformer system. PNAS. IF 11.1. Contributing Author

12.   Li Z, He J, Yin Y, Tang L, Liu Y, Monteiro O, Zeng F (21/12/2023). SARS-CoV-2 pathogenesis in the gastrointestinal tract mediated by Spike-induced intestinal inflammation. Precision Clinical Medicine. IF 5.3. Corresponding Author

13.   Ye Y, Sarkar S, Bhaskar A, Tomlinson B, Monteiro O (21/06/2023). Using ChatGPT in a clinical setting: A case report. MedComm – Future Medicine. Corresponding Author

14.   Baptista-Hon DT, Fesalbon GJW, Monteiro O (21/11/2022). Changing clinical features of the 2022 monkeypox global health emergency. MedComm – Future Medicine. Contributing Author

15.   Monteiro O (17/10/2022). How will previous infection or current vaccination strategies protect us from future SARS-CoV-2 variant infections? MedComm – Future Medicine. 1st Author

16.   Monteiro O, Li YW, Baptista-Hon DT (16/08/2022). Phylogenomic characterization of the 2022 outbreak of monkeypox virus—The importance of sustained genetic surveillance. MedComm – Future Medicine. 1st Author

17.   Zhou Z, Du P, Li N, Xiong X, Tang S, Dai Q, Wang T, Yu M, Man M, Lam K, Baptista-Hon DT, Tai WH, Monteiro O, Ng WS, Lee UM, Liu Z, Zhang K, Li G (June 2022). Homologous or heterogenous vaccination boosters enhance neutralizing activities against SARS-CoV-2 Omicron BA.1 variant. MedComm. IF 10.7. Contributing Author

18.   Monteiro O, Bhaskar A, Wong IN, Ng AKM, Baptista-Hon DT (Dec 2021). Teaching bioelectricity and neurophysiology to medical students using LabAXON simulations. Adv Physiol Ed. IF 2.89. 1st Author

19.   Monteiro O, Bhaskar A, Ng AKM, Murdoch CE, Baptista-Hon DT (Oct 2021). Computer-based virtual laboratory simulations: LabHEART cardiac physiology practical. Adv Physiol Ed. IF 2.89. 1st Author

20.   Monteiro O, Chen CW, Bingham R, Rowland P, Argyrou A, Buxton R, Pancevec C, Jones E, Bridges A, Gatfield K, Krauss S, Lambert J, Langston R, Schweiger S, Uings I (2018). Pharmacological disruption of the MID-1/α4 interaction reduces mutant Huntingtin levels in primary neuronal cultures. Neuroscience Letters 673, pp. 44-50. IF 2.026. Contributing Author

21.   King R, Monteiro O, Etherington L, Swinny J, Lambert JJ, Langston RF, Schweiger S (in preparation). Early cognitive and synaptic plasticity deficits in HdhQ111 mice are reversed by inhibition of α5-GABAA receptors. Neuropharmacology. IF 5.1026. Equal Contribution

22.   Arnoux I, Willam M, Griesche N, Krummeich J, Watari H, Offermann N, Weber S, Dey NP, Chen CW, Monteiro O, Buettner S, Meyer K, Bano D, Radyushkin K, Langston RF, Lambert JJ, Wanker E, Methner A, Krauss S, Schweiger S, Stroh A (2018). Early cortical network dysfunction and behavior changes in a mouse model of Huntington’s Disease can be reversed by Metformin. eLife. IF 7.725. Contributing Author

23.   Etherington L, Mihalik B, Pálvölgyi A, Ling I, Pallagi K, Gunn BG, Brown AR, Livesey MR, Monteiro O, Belelli D, Barkóczy J, Spedding M, Lambert JJ, Antoni FA (2017). Selective targeting of extra-synaptic α5-GABAA receptors by S44819 (Egis-13529), a novel competitive GABAA receptor inhibitor compound. Neuropharmacology 125, pp. 353-364. IF 5.1026. Contributing Author

24.   Monteiro O, Wiegand UK, Ludwig M (2011). Vesicle degradation in dendrites of magnocellular neurones of the rat supraoptic nucleus. Neuroscience Letters 489, pp. 30-33. IF 2.026. 1st Author

Books
Patents
Professional Certification and Awards

RESEARCH FUNDING

  • FDCT General research grant (2022 – 2025) Selective inhibition of GABAARs on the treatment of postoperative cognitive deficit (POCD) caused by anaesthesia. (Grant value MOP 1,400,000) Principal investigator

  •  FDCT General research grant (2022 – 2024) Effects of Sinopharm BBIBP-CorV and BioNTech mRNA primary vaccination series and homologous and heterologous booster shots against SARS-CoV2 variants of concern in a local population in Macao. (Grant value MOP 644,000) Principal investigator

  •  Macau University of Science and Technology Faculty Research Grant (2021-2022) - Relocalization of extrasynaptic α5-GABAA receptors causes memory loss and impairs long-term potentiation in a model of early life adversity (Grant value MOP 100,000).  Principal investigator.

  • FDCT General research grant (2021-2024) - The voltage-gated sodium channel NaV1.5 functions as an escape pathway from apoptosis in colon cancer cells (Grant value MOP 2,650,000). Co-investigator.

  • Society for Endocrinology Small Grant Programme for Scientific Research in Endocrinology (2007-2008) – Mechanisms for dendritic peptide release (Grant value MOP 113,330) Co-investigator.

  • The G Lawrence fund (University of Dundee) 2015 and 2018.

  •  Project and travel award for EMBO 3D developmental imaging course 2011


Professional Society Membership

·         Block coordinator for MBBS Foundation Block, Endocrine Block, Nervous System Block

·         Editor for Faculty Monograph II

·         Co-editor for Faculty Monograph I

·         Represented FMD for Institutional Accreditation

·         Represented FMD for Admissions talk

·         High school public engagement talks promoting FMD

·         Imaging Core Facility coordinator

·         Organiser for MSD Research Seminar Series

·         Organising committee for 2nd and 3rd Frontiers in Medicine Summits

·         Interviewer for MBBS admissions

·         Interviewer for DPBS PhD program admissions

·         Interviewer for SP PhD program admissions

·         Interviewer for SP MSc program admissions