LOK, SI CHONG
Associate Professor
Department: Faculty of Medicine
Office: Room PP-R206e, Est. Seak Pai Van Praia Park , Rés-Do-Chão R, Coloane, Macao
E-mail: sclok@must.edu.mo
Dr Lok completed his undergraduate medical training at the University of Cambridge, and subsequently undertook specialty training in respiratory medicine and general internal medicine in the UK. He also obtained his PhD at the University of Cambridge, working in research projects in human and murine immunology including imaging of immune cell dynamics. Following a period of postdoctoral research at Osaka University, Dr Lok returned to Macau and joined the Faculty of Medicine in 2024.
Academic Qualification

2020 PhD, University of Cambridge

2008 MA, University of Cambridge

2007 MB BChir, University of Cambridge

2004 BA, University of Cambridge


Teaching Area

Respiratory medicine, internal medicine, clinical medicine

Research Area

Immunology, neutrophils

Working Experience

2024-     Associate professor, Faculty of Medicine, MUST

2020-2024 Postdoctoral research fellow, Osaka University

2020-2020 Consultant in respiratory medicine, Cambridge University Hospitals, UK

2018-2020 Specialty registrar in respiratory and general medicine, UK

2013-2018 Clinical research fellow, University of Cambridge

2011-2013 Specialty registrar in respiratory and general medicine, UK

2007-2011 Foundation and core medical trainee, UK


Academic Publication (selected)

1.     Zhang Y, Garcia-Ibanez L, Ulbricht C, Lok LSC, Pike JA, Mueller-Winkler J et al. Recycling of memory B cells between germinal center and lymph node subcapsular sinus supports affinity maturation to antigenic drift. Nature Communications 2022;13(1):2460.

2.     Lok LSC, Clatworthy MR. Neutrophils in secondary lymphoid organs. Immunology 2021;164(4):677-88. (Joint corresponding authors)

3.     Lok LSC, Walker JA, Jolin HE, Scanlon ST, Ishii M, Fallon PG et al. Group 2 innate lymphoid cells exhibit tissue-specific dynamic behaviour during type 2 immune responses. Frontiers in Immunology 2021;12:711907.

4.     Jing C, Castro-Dopico T, Richoz N, Tuong ZK, Ferdinand JR, Lok LSC et al. Macrophage metabolic reprogramming presents a therapeutic target in lupus nephritis. Proceedings of the National Academy of Sciences of the United States of America 2020;117(26):15160-71.

5.     Lok LSC, Dennison TW, Mahbubani KM, Saeb-Parsy K, Chilvers ER, Clatworthy MR. Phenotypically distinct neutrophils patrol uninfected human and mouse lymph nodes. Proceedings of the National Academy of Sciences of the United States of America 2019;116(38):19083-9.

6.     Farahi N, Loutsios C, Tregay N, Wright AK, Berair R, Lok LSC et al. In vivo imaging reveals increased eosinophil uptake in the lungs of obese asthmatic patients. Journal of Allergy and Clinical Immunology 2018;142(5):1659-62.e8.

7.     Farahi N, Loutsios C, Tregay N, Summers C, Lok LSC, Ruparelia P et al. Radiolabelled leucocytes in human pulmonary disease. British Medical Bulletin 2018;127(1):69-82.

8.     Lok LSC, Farahi N, Juss JK, Loutsios C, Solanki CK, Peters AM et al. Effects of tocilizumab on neutrophil function and kinetics. European Journal of Clinical Investigation 2017;47(10):736-45.

9.     Nikolic MZ, Lok LSC, Mattishent K, Barth S, Yung B, Cummings NM et al. Non interventional statistical comparison of BTS and CHEST guidelines for size and severity in primary pneumothorax. European Respiratory Journal 2015;45(6):1731-4.


Books
Patents
Professional Certification and Awards

2018 Specialty Certificate in Respiratory Medicine, UK

2011 Associate of the Higher Education Academy (AHEA), UK

2010 Membership of the Royal College of Physicians (MRCP), UK


Professional Society Membership