Faculty of Medicine - Full time Academic Staff

YU, XI

Assistant Professor

Office: Room PP-R207d, Est. Seak Pai Van Praia Park , Rés-Do-Chão R, Coloane, Macau

E-mail: xyu@must.edu.mo

Dr. Yu Xi is currently an assistant professor at the Faculty of Medicine at Macau University of Science and Technology and a member of the Student Affairs Office. She graduated with a PhD from the Department of Food Science and Technology, School of Chemistry, National University of Singapore (2019 Outstanding Doctoral Graduate Award). She is currently mainly engaged in research in the fields of nanomaterials, separation and analytical chemistry, and food and nutrition science. She has published more than 60 papers so far in Published in various top industry journals, including Trends in Food Science & Technology, Comprehensive Reviews in Food Science and Food Safety, Analytical Chemistry，Analytical Chemistry，Journal of Agricultural and Food Chemistry，Food Chemistry etc., and her Google Scholar H-index is 21. She is currently on the youth editorial board of Food and Heath and Food Research and Development, and is a professional reviewer for many academic journals including Journal of Agricultural and Food Chemistry, Food Chemistry, etc. Her work has been reported by many professional media, including the Strait Times, one of the most influential English-language media in Asia, and Channel 8 News. Her research has been funded by the Arowana Nutrition and Safety Fund of Wilmar International, one of the world's largest food, grain and oil companies, and has received funding from the Macau Science and Technology Development Fund, the Sichuan International Science and Technology Innovation Cooperation Project, and the Zhuhai Industry-University-Research Cooperation Project, etc.

Academic Qualification

PhD National University of Singapore; MSc Jilin University; BSc Jilin University.

Teaching Area

Fundamental chemistry; Organic chemistry; Analytical chemistry; Biochemistry; Introduction to nutrition science; Mysterious materials.

Research Area

Food safety and nutritional sciences; Nanotechnoloy; Separation science; Analytical chemistry; Public Health.

Working Experience

2019-now assistant professor, Macau Univeristy of Science and Technology;

2018-2019 research fellow, Nanyang Technological University;

2013-2014 research assistant, Dalian Institute of Chemistry and Physics.

Academic Publication (selected)

1. He, G.; Chen, X.; Hou, X.; Yu, X.; Han, M.; Qiu, S.; Li, Y.; Qin, S.; Wang, F., UPLC-Q-TOF/MS-based metabolomic analysis reveals the effects of asomate on the citrus fruit. Current Research in Food Science 2023, 6, 100523.

2. Zhao, X.; Wang, A.; Zhai, L.; Gao, J.; Lyu, S.; Jiang, Y.; Zhong, T.; Xiao, Y.; Yu, X., Magnetic solid phase extraction coupled to HPLC-UV for highly sensitive analysis of mono-hydroxy polycyclic aromatic hydrocarbons in urine. Analytica Chimica Acta 2024, 1285, 342020.

3. Zhao, X.; Feng, X.; Chen, J.; Zhang, L.; Zhai, L.; Lv, S.; Ye, Y.; Chen, Y.; Zhong, T.; Yu, X.; Xiao, Y., Rapid and Sensitive Detection of Polycyclic Aromatic Hydrocarbons in Tea Leaves Using Magnetic Approach. Foods 2023, 12 (11), 2270.

4. Zhao, X.; Gao, J.; Zhai, L.; Yu, X.; Xiao, Y. Recent Evidence on Polycyclic Aromatic Hydrocarbon Exposure Healthcare [Online], 2023.

5. Lu, Y.; Li, Z.; Chen, Q.; Fan, Y.; Wang, J.; Ye, Y.; Chen, Y.; Zhong, T.; Wang, L.; Xiao, Y.; Zhang, D.; Yu, X., Association of working hours and cumulative fatigue among Chinese primary health care professionals. Frontiers in Public Health 2023, 11.

6. Zhang, Y.; Qiu, J.; Yang, K.; Lu, Y.; Xu, Z.; Yang, H.; Xu, Y.; Wang, L.; Lin,

Y.; Tong, X.; He, J.; Xiao, Y.; Sun, X.; Huang, R.; Yu, X.; Zhong, T., Generation, mechanisms, kinetics, and effects of gaseous chlorine dioxide in food preservation. Comprehensive Reviews in Food Science and Food Safety 2023, 22 (4), 3105-3129.

7. Wang, A.; Feng, X.; He, G.; Xiao, Y.; Zhong, T.; Yu, X., Recent advances in digital microfluidic chips for food safety analysis: Preparation, mechanism and application. Trends in Food Science & Technology 2023, 134, 136-148.

8. Fu, C.; Guo, H.; You, C.; Yu, X., Recent Advances and Product Opportunities in the Technology of Proteins, Probiotics and Prebiotics. 2023.

9. Yu, X.; Zuo, T., Editorial: Food Additives, Cooking and Processing: Impact on the Microbiome. Frontiers in Nutrition 2021, 8.

10. Ahmad, T.; Nie, C.; Cao, C.; Xiao, Y.; Yu, X.; Liu, Y., First record of Alternaria tenuissima causing Aloe barbadensis leaf blight and leaf spot disease in Beijing, China. Crop Protection 2024, 175, 106447.

11. Cen, K.; Huang, C.; Yu, X.; Gao, C.; Yang, Y.; Tang, X.; Feng, X., Quinoa protein Pickering emulsion: A promising cryoprotectant to enhance the

freeze-thaw stability of fish myofibril gels. Food Chemistry 2023, 407, 135139.

12. He, G.; Hou, X.; Han, M.; Qiu, S.; Yu, X.; Qin, S.; Wang, F.; Li, Y.,Determination of multiclass contaminants in chilli powder based on magnetic multiwalled carbon nanotubes and UPLC-QTOF/MS. Food Research International 2023, 173, 113263.

13. Feng, X.; Cen, K.; Yu, X.; Huang, C.; Yang, W.; Yang, Y.; Tang, X., Quinoa protein Pickering emulsion improves the freeze-thaw stability of myofibrillar protein gel: Maintaining protein composition, structure, conformation and digestibility and slowing down protein oxidation. International Journal of Biological Macromolecules 2023, 253, 126682.

14. Jiang, T.; Dong, Y.; Zhu, W.; Wu, T.; Chen, L.; Cao, Y.; Yu, X.; Peng, Y.; Wang, L.; Xiao, Y.; Zhong, T., Underlying mechanisms and molecular targets of genistein in the management of type 2 diabetes mellitus and related complications. Critical Reviews in Food Science and Nutrition 2023, 1-13.

15. Feng, X.; Yu, X.; Yang, Y.; Tang, X., Improving the freeze-thaw stability of fish myofibrils and myofibrillar protein gels: Current methods and future perspectives. Food Hydrocolloids 2023, 144, 109041.

16. Wu, T.; Zhu, W.; Chen, L.; Jiang, T.; Dong, Y.; Wang, L.; Tong, X.; Zhou, H.; Yu, X.; Peng, Y.; Wang, L.; Xiao, Y.; Zhong, T., A review of natural plant extracts in beverages: Extraction process, nutritional function, and safety evaluation. Food Research International 2023, 172, 113185.

17. Chen, S.; Feng, X.; Yu, X., Editorial: Advances on innovative

protein-based complexes with promising functionality, nutrient retention and encapsulation capacity. Frontiers in Nutrition 2023, 10.

18. Jiang, D.; Yu, X.; Zhong, T.; Xiao, Y.; Wang, L., The Situation and Influencing Factors of Depression and Anxiety in Patients of Hemodialysis during the COVID-19 Pandemic in China. Healthcare 2023, 11 (7), 941.

19. Ahmad, T.; Xing, F.; Nie, C.; Cao, C.; Xiao, Y.; Yu, X.; Moosa, A.; Liu, Y., Biocontrol potential of lipopeptides produced by the novel Bacillus subtilis strain Y17B against postharvest Alternaria fruit rot of cherry. Frontiers in Microbiology 2023, 14.

20. Wolfe, W.; Xiang, Z.; Yu, X.; Li, P.; Chen, H.; Yao, M.; Fei, Y.; Huang, Y.; Yin, Y.; Xiao, H., The Challenge of Applications of Probiotics in Gastrointestinal Diseases. Advanced Gut & Microbiome Research 2023, 2023, 1984200.

21. Gao, J.; Xu, Y.; Zhong, T.; Yu, X.; Wang, L.; Xiao, Y.; Peng, Y.; Sun, Q., A review of food contaminant 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin and its toxicity associated with metabolic disorders. Current Research in Food Science 2023, 100617.

22. Li, X.; Zhu, S.; Zhang, X.; Ren, Y.; He, J.; Zhou, J.; Yin, L.; Wang, G.;Zhong, T.; Wang, L.; Xiao, Y.; Zhu, C.; Yin, C.; Yu, X., Advances in the application of recombinase-aided amplification combined with CRISPR-Cas technology in quick detection of pathogenic microbes. Frontiers in Bioengineering and Biotechnology 2023, 11.

23. Liu, Y.; Zhu, L.; Yu, X.; Xu, Y.; Zhong, T., A Combined

Ultrasound–Microwave Assisted Alcoholic–Alkaline Method for Preparation of Granulated Cold-Water-Soluble Starch. Starch - Stärke 2023, n/a (n/a), 2200257.

24. Qiu, J.; Yang, H.; Zhang, Y.; Xiao, Y.; Wang, L.; Peng, Y.; Yu, X.; Huang, X.; Zhong, T., Emerging trends in the application of riboflavin-mediated photodynamic inactivation for food preservation. Trends in Food Science & Technology 2023, 104295.

25. Dong, Y.; Jiang, T.; Wu, T.; Wang, W.; Xie, Z.; Yu, X.; Peng, Y.; Wang, L.; Xiao, Y.; Zhong, T., Enzyme-responsive controlled-release materials for food preservation and crop protection-A review. International Journal of Biological Macromolecules 2023, 128051.

26. Ahmad, T.; Li, G.; Wang, J.; Li, M.; Xiao, Y.; Yu, X.; Zheng, Y.; Moosa, A.; Nie, C.; Liu, Y., First Report of Bacterial Leaf Spot of Ficus benghalensis Caused by Pseudomonas cichorii in Pakistan. Plant Disease 2022, 107 (2), 552.

27. Tao, A.; Zhang, H.; Duan, J.; Xiao, Y.; Liu, Y.; Li, J.; Huang, J.; Zhong, T.; Yu, X., Mechanism and application of fermentation to remove beany flavor from plant-based meat analogs: A mini review. Frontiers in Microbiology 2022, 13.

28. Lu, Y.; Li, Z.; Fan, Y.; Wang, J.; Zhong, T.; Wang, L.; Xiao, Y.; Zhang, D.; Chen, Q.; Yu, X., The Mediating Role of Cumulative Fatigue on the Association between Occupational Stress and Depressive Symptoms: A Cross-Sectional Study among 1327 Chinese Primary Healthcare Professionals. International Journal of Environmental Research and Public Health 2022, 19 (23), 15477.

29. Li, Z.; Li, S.; Xiao, Y.; Zhong, T.; Yu, X.; Wang, L., Nutritional intervention for diabetes mellitus with Alzheimer's disease. Frontiers in Nutrition 2022, 9.

30. Cen, K.; Yu, X.; Gao, C.; Yang, Y.; Tang, X.; Feng, X., Effects of quinoa protein Pickering emulsion on the properties, structure and intermolecular interactions of myofibrillar protein gel. Food Chemistry 2022, 394, 133456.

31. Tao, X.; Shao, Y.; Xu, D.; Huang, Y.; Yu, X.; Zhong, T.; Wang, L.; Chung, S. K.; Chen, D.; Yu, L.; Xiao, Y., Dietary Patterns and Nutrient Intake in University Students of Macao: A Cross-Sectional Study. Nutrients 2022, 14 (17), 3642.

32. Li, X.; Su, L.; Zhang, X.; Chen, Q.; Wang, Y.; Shen, Z.; Zhong, T.; Wang, L.; Xiao, Y.; Feng, X.; Yu, X., Recent Advances on the Function and Purification of Milk Exosomes: A Review. Frontiers in Nutrition 2022, 9.

33. Lin, Y.; Huang, R.; Sun, X.; Yu, X.; Xiao, Y.; Wang, L.; Hu, W.; Zhong, T., The p-Anisaldehyde/β-cyclodextrin inclusion complexes as a sustained release agent: Characterization, storage stability, antibacterial and antioxidant activity. Food Control 2022, 132, 108561.

34. Su, B.; Zhang, Z.; Sun, Z.; Tang, Z.; Xie, X.; Chen, Q.; Cao, H.; Yu, X.; Xu,

Y.; Liu, X.; Hammock, B. D., Fluonanobody-based nanosensor via fluorescence resonance energy transfer for ultrasensitive detection of ochratoxin A. Journal of Hazardous Materials 2022, 422, 126838.

35. Li, X.; Ren, Y.; Liu, D.; Yu, X.; Chen, K., Role of miR-100-5p and CDC25A in breast carcinoma cells. PeerJ 2022, 10, e12263.

36. Yu, X.; Zhong, T.; Zhang, Y.; Zhao, X.; Xiao, Y.; Wang, L.; Liu, X.; Zhang, X., Design, Preparation, and Application of Magnetic Nanoparticles for Food Safety Analysis: A Review of Recent Advances. Journal of Agricultural and Food Chemistry 2022, 70 (1), 46-62.

37. Tao, X.; Chen, D.; Fan, Y.; Zhang, L.; Shan, H.; Wei, Y.; Yu, X.; Zhong, T.; Wang, L.; Chung, S. K.; Yu, Y.; Xiao, Y., A cross-sectional study for the mental health status and sleep quality among college students in Macao during the COVID-19 pandemic. PeerJ 2021, 9, e12520.

38. Cen, K.; Yu, X.; Gao, C.; Feng, X.; Tang, X., Effects of different vegetable oils and ultrasonicated quinoa protein nanoparticles on the rheological properties of Pickering emulsion and freeze-thaw stability of emulsion gels. Journal of Cereal Science 2021, 102, 103350.

39. Ge, Y.; Li, N.; Fu, Y.; Yu, X.; Xiao, Y.; Tang, Z.; Xiao, J.; Wu, J.-L.; Jiang, Z.-H., Deciphering superior quality of Pu-erh tea from thousands of years’ old trees based on the chemical profile. Food Chemistry 2021, 358, 129602.

40. Zhong, T.; Yu, X.; Xiao, Y.; Wang, L.; Tan, L.; Huang, R., Incorporating lipid microparticles into carboxymethyl cellulose films as secondary carriers for stable loading and sustained releasing of carvacrol. Results in Materials 2021, 11, 100205.

41. Huang, S.; Palanisamy, S.; Yu, X.; Wang, Y.; Liu, D.; Gong, W.; Zhang, X., α-Active Pyrylium Salt 2,4,5-Triphenylpyrylium for Improved Mass Spectrometry-Based Detection of Peptides. Analytical Chemistry 2021, 93 (32), 11072-11080.

42. Tao, X.; Chen, D.; Liang, R.; Zhang, X.; Yu, X.; Chung, S.; Yu, Y.; Xiao, Y., A comparative study on knowledge towards COVID-19 prevention among undergraduate students in Macao and Zhuhai, China. PeerJ 2021, 9, e11833.43. Yu, X.; Lee, J. K.; Liu, H.; Yang, H., Synthesis of magnetic nanoparticles to detect Sudan dye adulteration in chilli powders. Food Chemistry 2019, 299, 125144.

44. Yu, X.; Lim, C. Y. X.; Dong, B.; Hadinoto, K., Development of magnetic solid phase extraction platform for the purification of bioactive γ-glutamyl peptides from garlic (Allium sativum). LWT 2020, 127, 109410.

45. Yu, X.; Li, Z.; Zhao, M.; Lau, S. C. S.; Ru Tan, H.; Teh, W. J.; Yang, H.; Zheng, C.; Zhang, Y., Quantification of aflatoxin B1 in vegetable oils using low temperature clean-up followed by immuno-magnetic solid phase extraction. Food Chemistry 2019, 275, 390-396.

46. Zheng, Y.; Yu, X.; Yang, H.; Wang, S., Chapter 5 - From a Perspective of Nutrition: Importance of Organic Foods over Conventional Counterparts. In Safety and Practice for Organic Food, Biswas, D.; Micallef, S. A., Eds. Academic Press: 2019; pp 75-134.

47. Yu, X.; Li, Y.; Ng, M.; Yang, H.; Wang, S., Comparative study of pyrethroids residue in fruit peels and fleshes using polystyrene-coated magnetic nanoparticles based clean-up techniques. Food Control 2018, 85, 300-307.

48. Yu, X.; Ang, H. C.; Yang, H.; Zheng, C.; Zhang, Y., Low temperature cleanup combined with magnetic nanoparticle extraction to determine pyrethroids residue in vegetables oils. Food Control 2017, 74, 112-120.

49. Yu, X.; Yang, H., Pyrethroid residue determination in organic and conventional vegetables using liquid-solid extraction coupled with magnetic solid phase extraction based on polystyrene-coated magnetic nanoparticles. Food Chemistry 2017, 217, 303-310.

50. Yu, X.; Sun, Y.; Jiang, C.-Z.; Gao, Y.; Wang, Y.-P.; Zhang, H.-Q.; Song, D.-Q., Magnetic solid-phase extraction and ultrafast liquid chromatographic detection of Sudan dyes in red wines, juices, and mature vinegars. Journal of Separation Science 2012, 35 (23), 3403-3411.

51. Yu, X.; Sun, Y.; Jiang, C.; Sun, X.; Gao, Y.; Wang, Y.; Zhang, H.; Song, D., Magnetic solid-phase extraction of five pyrethroids from environmental water samples followed by ultrafast liquid chromatography analysis. Talanta 2012, 98, 257-264.

52. Jiang, C.; Sun, Y.; Yu, X.; Zhang, L.; Sun, X.; Gao, Y.; Zhang, H.; Song, D., Removal of sudan dyes from water with C18-functional ultrafine magnetic silica nanoparticles. Talanta 2012, 89, 38-46.

53. Sun, X.-M.; Sun, Y.; Wu, L.-W.; Jiang, C.-Z.; Yu, X.; Gao, Y.; Wang, L.-Y.; Song, D.-Q., Development of a vortex-assisted ionic liquid microextraction method for the determination of aromatic amines in environmental water samples. Analytical Methods 2012, 4 (7), 2074-2080.

54. Jiang, C.; Sun, Y.; Yu, X.; Gao, Y.; Zhang, L.; Wang, Y.; Zhang, H.; Song, D., Liquid–solid extraction coupled with magnetic solid-phase extraction for determination of pyrethroid residues in vegetable samples by ultra fast liquid chromatography. Talanta 2013, 114, 167-175.

55. Gao, Y.; Sun, Y.; Jiang, C.; Yu, X.; Wang, Y.; Zhang, H.; Song, D., Fast Determination of Pyrethroid Pesticides in Tobacco by GC-MS-SIM Coupled with Modified QuEChERS Sample Preparation Procedure. Analytical Sciences 2013, 29 (6), 649-653.

56. Yu, X.; Khani, A.; Ye, X.; Petruzziello, F.; Gao, H.; Zhang, X.; Rainer, G., High-Efficiency Recognition and Identification of Disulfide Bonded Peptides in Rat Neuropeptidome Using Targeted Electron Transfer Dissociation Tandem Mass Spectrometry. Analytical Chemistry 2015, 87 (23), 11646-11651.

57. Wang, Y.; Sun, Y.; Wang, Y.; Jiang, C.; Yu, X.; Gao, Y.; Zhang, H.; Song, D., Determination of Sudan dyes in environmental water by magnetic mesoporous microsphere-based solid phase extraction ultra fast liquid chromatography. Analytical Methods 2013, 5 (6), 1399-1406.

58. Jiang, C.; Sun, Y.; Yu, X.; Gao, Y.; Zhang, L.; Wang, Y.; Zhang, H.; Song, D., Application of C18-functional magnetic nanoparticles for extraction of aromatic amines from human urine. Journal of Chromatography B 2014,947-948, 49-56.

59. Ye, X.; Zhao, N.; Yu, X.; Han, X.; Gao, H.; Zhang, X., Extensive characterization of peptides from Panax ginseng C. A. Meyer using mass spectrometric approach. PROTEOMICS 2016, 16 (21), 2788-2791.

60. Liu, Y.; Zhu, L.; Yu, X.; Xu, Y.; Zhong, T., A Combined Ultrasound–

Microwave Assisted Alcoholic–Alkaline Method for Preparation of Granulated Cold‐Water‐Soluble Starch. Starch‐Stärke 2023, 75 (11-12),

2200257.

61. Jiang, T.; Dong, Y.; Zhu, W.; Wu, T.; Chen, L.; Cao, Y.; Yu, X.; Peng, Y.; Wang, L.; Xiao, Y., Underlying mechanisms and molecular targets of genistein in the management of type 2 Diabetes Mellitus and related Complications. Critical Reviews in Food Science and Nutrition 2023, 1-13.

62. Feng, X.; Yu, X.; Yang, Y.; Tang, X., Improving the freeze-thaw stability of fish myofibrils and myofibrillar protein gels: Current methods and future perspectives. Food Hydrocolloids 2023, 109041.

Books

1. Safety and Practice for Organic Food, Chapter 5: From a Perspective of Nutrition: Importance of Organic Foods over Conventional Counterparts. Zheng Y; Yu X; Yang H*; Wang S. Elsevier. 2019. ISBN: 978-0-12-812060-6.

Patents

1. Novel detection method for Sudan dye pollution in water，Song D，Sun Y，Jiang C，Yu X，Zhang L，Sun X，Gao Y. Patent No.: ZL201110157977.0, Date of Issuance: Nov. 14th, 2012.

Professional Certification and Awards

“Best Postgraduate Award”, Department of Food Science and Technology, National University of Singapore; “Award of Excellence”, Top 1st of Analytical Chemistry and Energy/Environment Category, Chemistry Graduate Symposium, National University of Singapore; “Honoured Graduate” and National Graduate Scholarship, Jilin U niversity.

Professional Society Membership

Member of editorial board for Advanced Gut & Microbiome Research, Food and Health; Member of youth editorial board for Food Research & Dvelopment; Guest editor for Foods, Frontiers in Nutrtion, Journal of Food Processing and Preservation, Healthcare; Member of Chinese Nutrition Society; Committee member of Students' Affairs Office, MUST